| Round | Overall | Player |
|---|---|---|
| 1 | 6th | OF Juan Soto Was |
| 2 | 19th | SS Trea Turner Was |
| 3 | 30th | 3B Jose Ramirez Cle |
| 4 | 43rd | OF Charlie Blackmon Col |
| 5 | 54th | SP Lucas Giolito ChA |
| 6 | 67th | OF Luis Robert Jr. ChA |
| 7 | 78th | SP Brandon Woodruff Mil |
| 8 | 91st | SP Sean Manaea Oak |
| 9 | 102nd | C Mitch Garver Min |
| 10 | 115th | SP Masahiro Tanaka NYA |
| 11 | 126th | OF Ramón Laureano Oak |
| 12 | 139th | RP Brandon Workman Bos |
| 13 | 150th | 1B Yulieski Gurriel Hou |
| 14 | 163rd | OF Kyle Schwarber ChN |
| 15 | 174th | 2B Cesar Hernández Cle |
| 16 | 187th | RP Will Smith Atl |
| 17 | 198th | OF Danny Santana Tex |
| 18 | 211th | RP Jose Leclerc Tex |
| 19 | 222nd | SP Michael Fiers Oak |
| 20 | 235th | 1B Eric Hosmer SD |
| 21 | 246th | SP Marco Gonzales Sea |
| 22 | 259th | 3B Asdrubal Cabrera Was |
| 23 | 270th | SS Willy Adames TB |
| 24 | 283rd | 2B Luis Arraez Min |
| 25 | 294th | 1B Ryan O'Hearn KC |
| 26 | 307th | SP Nate Pearson Tor |
| 27 | 318th | C Danny Jansen Tor |
| 28 | 331st | SS Niko Goodrum Det |
| 29 | 342nd | SP Spencer Howard Phi |