| Round | Overall | Player |
|---|---|---|
| 1 | 12th | SS Francisco Lindor Cle |
| 2 | 13th | OF Joey Gallo Tex |
| 3 | 36th | 1B Matt Olson Oak |
| 4 | 37th | SP Mike Clevinger SD |
| 5 | 60th | SP Frankie Montas Oak |
| 6 | 61st | 3B Manny Machado SD |
| 7 | 84th | OF Nick Castellanos Cin |
| 8 | 85th | OF Marcell Ozuna Atl |
| 9 | 108th | SP Max Fried Atl |
| 10 | 109th | C Yasmani Grandal ChA |
| 11 | 132nd | SP Corey Kluber Tex |
| 12 | 133rd | SP Lance Lynn Tex |
| 13 | 156th | 2B Rougned Odor Tex |
| 14 | 157th | SP Mike Foltynewicz Atl |
| 15 | 180th | OF Mark Canha Oak |
| 16 | 181st | 2B Starlin Castro Was |
| 17 | 204th | 3B Justin Turner LAD |
| 18 | 205th | 1B C.J. Cron Det |
| 19 | 228th | OF Gregory Polanco Pit |
| 20 | 229th | C Sean Murphy Oak |
| 21 | 252nd | SP Sandy Alcantara Mia |
| 22 | 253rd | SP Kwang-Hyun Kim StL |
| 23 | 276th | OF Mike Yastrzemski SF |
| 24 | 277th | SP Chris Archer Pit |
| 25 | 300th | SP Michael Kopech ChA |
| 26 | 301st | SS Nick Ahmed Ari |
| 27 | 324th | OF Teoscar Hernández Tor |
| 28 | 325th | SP Griffin Canning LAA |
| 29 | 348th | 1B Jesus Aguilar Mia |