| Round | Overall | Player |
|---|---|---|
| 1 | 10th | SP Jacob deGrom NYN |
| 2 | 15th | SP Shane Bieber Cle |
| 3 | 34th | 3B Rafael Devers Bos |
| 4 | 39th | OF Kyle Tucker Hou |
| 5 | 58th | SP Kenta Maeda Min |
| 6 | 63rd | SS Tim Anderson ChA |
| 7 | 82nd | OF Lourdes Gurriel Tor |
| 8 | 87th | OF Eddie Rosario Cle |
| 9 | 106th | SP Corbin Burnes Mil |
| 10 | 111th | SP Hyun-Jin Ryu Tor |
| 11 | 130th | 1B Christian Walker Ari |
| 12 | 135th | 3B Jeff McNeil NYN |
| 13 | 154th | SP Dinelson Lamet SD |
| 14 | 159th | 3B Ryan Mountcastle Bal |
| 15 | 178th | SP Pablo Lopez Mia |
| 16 | 183rd | SS Dansby Swanson Atl |
| 17 | 202nd | OF Jarred Kelenic Sea |
| 18 | 207th | OF Tommy Edman StL |
| 19 | 226th | OF Ramón Laureano Oak |
| 20 | 231st | SP Michael Pineda Min |
| 21 | 250th | 2B Tommy La Stella SF |
| 22 | 255th | OF Jesse Winker Cin |
| 23 | 274th | SP Framber Valdez Hou |
| 24 | 279th | OF Mark Canha Oak |
| 25 | 298th | SP Luis Severino NYA |
| 26 | 303rd | 2B Ty France Sea |
| 27 | 322nd | C Alejandro Kirk Tor |
| 28 | 327th | SP Ryan Yarbrough TB |
| 29 | 346th | 1B Nate Lowe Tex |