| Round | Overall | Player |
|---|---|---|
| 1 | 1st | 1B Vladimir Guerrero Jr. Tor |
| 2 | 24th | 3B Manny Machado SD |
| 3 | 25th | 2B Jose Altuve Hou |
| 4 | 48th | SP Lucas Giolito ChA |
| 5 | 49th | OF Cedric Mullins II Bal |
| 6 | 72nd | SP Aaron Nola Phi |
| 7 | 73rd | SS Corey Seager Tex |
| 8 | 96th | SP Framber Valdez Hou |
| 9 | 97th | OF Jesse Winker Mil |
| 10 | 120th | SP Frankie Montas NYA |
| 11 | 121st | OF Austin Meadows Det |
| 12 | 144th | SP Luis Severino NYA |
| 13 | 145th | 3B Josh Donaldson NYA |
| 14 | 168th | RP Mark Melancon Ari |
| 15 | 169th | RP Taylor Rogers Mil |
| 16 | 192nd | SP Chris Sale Bos |
| 17 | 193rd | C Mitch Garver Tex |
| 18 | 216th | OF Robbie Grossman Det |
| 19 | 217th | 2B Cavan Biggio Tor |
| 20 | 240th | 1B Yulieski Gurriel Hou |
| 21 | 241st | OF Kike Hernandez Bos |
| 22 | 264th | SS J.P. Crawford Sea |
| 23 | 265th | SP Nestor Cortes Jr. NYA |
| 24 | 288th | OF Mark Canha NYN |
| 25 | 289th | RP Joe Barlow Tex |
| 26 | 312th | 3B Yandy Diaz TB |
| 27 | 313th | SP Drew Rasmussen TB |
| 28 | 336th | C Kyle Farmer Cin |
| 29 | 337th | SP Dallas Keuchel Ari |