| Round | Overall | Player |
|---|---|---|
| 1 | 1st | 1B Vladimir Guerrero Jr Tor |
| 2 | 24th | 3B Alex Bregman Hou |
| 3 | 25th | SP Corbin Burnes Mil |
| 4 | 48th | OF Nick Castellanos Cin |
| 5 | 49th | OF Teoscar Hernández Tor |
| 6 | 72nd | C J.T. Realmuto Phi |
| 7 | 73rd | SP Aaron Nola Phi |
| 8 | 96th | DH J.D. Martinez Bos |
| 9 | 97th | OF Randy Arozarena TB |
| 10 | 120th | SP Chris Bassitt Tor |
| 11 | 121st | SP Jack Flaherty StL |
| 12 | 144th | SS Adalberto Mondesà KC |
| 13 | 145th | 2B Ryan McMahon Col |
| 14 | 168th | OF Jarred Kelenic Sea |
| 15 | 169th | SP Marco Gonzales Sea |
| 16 | 192nd | SP Joe Ryan Min |
| 17 | 193rd | SP Tyler Mahle Min |
| 18 | 216th | SP Zac Gallen Ari |
| 19 | 217th | 3B Ke'Bryan Hayes Pit |
| 20 | 240th | SP Zach Plesac Cle |
| 21 | 241st | SP Trevor Bauer LAD |
| 22 | 264th | SP Kyle Gibson Phi |
| 23 | 265th | C Joey Bart SF |
| 24 | 288th | 2B Adam Frazier Sea |
| 25 | 289th | 1B Carlos Santana KC |
| 26 | 312th | 2B David Fletcher LAA |
| 27 | 313th | SP Brad Keller KC |
| 28 | 336th | SP Pat Corbin Was |
| 29 | 337th | SP Adrian Houser Mil |