| Round | Overall | Player |
|---|---|---|
| 1 | 9th | OF Mookie Betts LAD |
| 2 | 16th | OF Yordan Alvarez Hou |
| 3 | 33rd | OF George Springer Tor |
| 4 | 40th | 1B Rhys Hoskins Phi |
| 5 | 57th | 2B Brandon Lowe TB |
| 6 | 64th | 3B Matt Chapman Tor |
| 7 | 81st | SS Tim Anderson ChA |
| 8 | 88th | RP Ryan Pressly Hou |
| 9 | 105th | RP Robert Suarez SD |
| 10 | 112th | SP Clayton Kershaw LAD |
| 11 | 129th | OF Dylan Carlson StL |
| 12 | 136th | SP Pablo Lopez Mia |
| 13 | 153rd | SP Aaron Civale Cle |
| 14 | 160th | SP Hunter Greene Cin |
| 15 | 177th | RP Jacob McGee SF |
| 16 | 184th | SP Hyun-Jin Ryu Tor |
| 17 | 201st | SP Jesus Luzardo Mia |
| 18 | 208th | SP Dakota Hudson StL |
| 19 | 225th | 2B Cavan Biggio Tor |
| 20 | 232nd | 1B Bobby Bradley Cle |
| 21 | 249th | OF Michael Brantley Hou |
| 22 | 256th | 3B Patrick Wisdom ChN |
| 23 | 273rd | SS Bryson Stott Phi |
| 24 | 280th | OF Robbie Grossman Det |
| 25 | 297th | SP Reid Detmers LAA |
| 26 | 304th | C Carson Kelly Ari |
| 27 | 321st | C Max Stassi LAA |
| 28 | 328th | 1B Christian Walker Ari |
| 29 | 345th | RP Emilio Pagan Min |