| Round | Overall | Player |
|---|---|---|
| 1 | 4th | 2B Mookie Betts LAD |
| 2 | 21st | 2B Jose Altuve Hou |
| 3 | 28th | 3B Manny Machado SD |
| 4 | 45th | OF Cody Bellinger ChN |
| 5 | 52nd | SP Max Fried Atl |
| 6 | 69th | OF Randy Arozarena TB |
| 7 | 76th | SP Cole Ragans KC |
| 8 | 93rd | SP Zach Eflin TB |
| 9 | 100th | 1B Vinnie Pasquantino KC |
| 10 | 117th | OF Nick Castellanos Phi |
| 11 | 124th | OF Christopher Morel ChN |
| 12 | 141st | 1B Anthony Rizzo NYA |
| 13 | 148th | SP Shota Imanaga ChN |
| 14 | 165th | SP Cristian Javier Hou |
| 15 | 172nd | SP Bryan Woo Sea |
| 16 | 189th | SS C.J. Abrams Was |
| 17 | 196th | SP Kyle Harrison SF |
| 18 | 213th | SP Marcus Stroman NYA |
| 19 | 220th | OF Jarren Duran Bos |
| 20 | 237th | C Henry Davis Pit |
| 21 | 244th | SP Nestor Cortes Jr. NYA |
| 22 | 261st | SS J.P. Crawford Sea |
| 23 | 268th | 2B Brendan Rodgers Col |
| 24 | 285th | SP Kenta Maeda Det |
| 25 | 292nd | 3B Maikel Garcia KC |
| 26 | 309th | C Austin Wells NYA |
| 27 | 316th | SP Casey Mize Det |
| 28 | 333rd | SP Andrew Heaney Tex |
| 29 | 340th | OF Sal Frelick Mil |