| Round | Overall | Player |
|---|---|---|
| 1 | 5th | SS Bobby Witt Jr. KC |
| 2 | 20th | OF Corbin Carroll Ari |
| 3 | 29th | 2B Marcus Semien Tex |
| 4 | 44th | 3B Alex Bregman Hou |
| 5 | 53rd | RP Josh Hader Hou |
| 6 | 68th | OF Evan Carter Tex |
| 7 | 77th | 1B Spencer Torkelson Det |
| 8 | 92nd | SP Dylan Cease SD |
| 9 | 101st | SP Mitch Keller Pit |
| 10 | 116th | C William Contreras Mil |
| 11 | 125th | RP Peter Fairbanks TB |
| 12 | 140th | 1B Josh Naylor Cle |
| 13 | 149th | OF Josh Lowe TB |
| 14 | 164th | SP Brayan Bello Bos |
| 15 | 173rd | SP Gavin Williams Cle |
| 16 | 188th | RP José Alvarado Phi |
| 17 | 197th | SP Eduardo Rodriguez Ari |
| 18 | 212th | 2B Jorge Polanco Sea |
| 19 | 221st | OF Steven Kwan Cle |
| 20 | 236th | SS Jeremy Pena Hou |
| 21 | 245th | C Jonah Heim Tex |
| 22 | 260th | SP Cristopher Sanchez Phi |
| 23 | 269th | 3B Yoan Moncada ChA |
| 24 | 284th | 1B Carlos Santana Min |
| 25 | 293rd | SP Yusei Kikuchi Tor |
| 26 | 308th | 1B Jake Cronenworth SD |
| 27 | 317th | OF Austin Hays Bal |
| 28 | 332nd | 1B Kyle Manzardo Cle |
| 29 | 341st | SP Braxton Garrett Mia |