| Round | Overall | Player |
|---|---|---|
| 1 | 2nd | OF Juan Soto NYA |
| 2 | 23rd | 3B Rafael Devers Bos |
| 3 | 26th | SS Francisco Lindor NYN |
| 4 | 47th | SP George Kirby Sea |
| 5 | 50th | SP Yoshinobu Yamamoto LAD |
| 6 | 71st | SP Tarik Skubal Det |
| 7 | 74th | OF Seiya Suzuki ChN |
| 8 | 95th | SP Jesus Luzardo Mia |
| 9 | 98th | OF Spencer Steer Cin |
| 10 | 119th | 2B Xander Bogaerts SD |
| 11 | 122nd | 1B Jeimer Candelario Cin |
| 12 | 143rd | C J.T. Realmuto Phi |
| 13 | 146th | DH J.D. Martinez NYN |
| 14 | 167th | RP Craig Kimbrel Bal |
| 15 | 170th | OF Cedric Mullins Bal |
| 16 | 191st | SS Jackson Holliday Bal |
| 17 | 194th | RP Alex Lange Det |
| 18 | 215th | SP Ryan Pepiot TB |
| 19 | 218th | SP Max Scherzer Tex |
| 20 | 239th | SP Triston McKenzie Cle |
| 21 | 242nd | OF Ceddanne Rafaela Bos |
| 22 | 263rd | 2B Jordan Westburg Bal |
| 23 | 266th | SP James Paxton LAD |
| 24 | 287th | OF Will Benson Cin |
| 25 | 290th | OF Nelson Velazquez KC |
| 26 | 311th | SP Kutter Crawford Bos |
| 27 | 314th | SP Louie Varland Min |
| 28 | 335th | SS Geraldo Perdomo Ari |
| 29 | 338th | C Gary Sanchez Mil |