| Round | Overall | Player |
|---|---|---|
| 1 | 2nd | SS Bobby Witt Jr. KC |
| 2 | 23rd | 3B Austin Riley Atl |
| 3 | 26th | SP Tarik Skubal Det |
| 4 | 47th | 2B Jazz Chisholm Jr. NYA |
| 5 | 50th | OF Anthony Santander Tor |
| 6 | 71st | SP Chris Sale Atl |
| 7 | 74th | OF Lawrence Butler Oak |
| 8 | 95th | 1B Vinnie Pasquantino KC |
| 9 | 98th | OF Luis Robert Jr. ChA |
| 10 | 119th | OF Colton Cowser Bal |
| 11 | 122nd | SP Bailey Ober Min |
| 12 | 143rd | C Shea Langeliers Oak |
| 13 | 146th | SP Robbie Ray SF |
| 14 | 167th | SP Seth Lugo KC |
| 15 | 170th | SP Grayson Rodriguez Bal |
| 16 | 191st | 1B Ryan Mountcastle Bal |
| 17 | 194th | 2B Luis Garcia Was |
| 18 | 215th | SP Nestor Cortes Jr. Mil |
| 19 | 218th | 3B Nolan Arenado StL |
| 20 | 239th | OF Michael Conforto LAD |
| 21 | 242nd | SP Luis Gil NYA |
| 22 | 263rd | SS Zach Neto LAA |
| 23 | 266th | RP Ryan Pressly ChN |
| 24 | 287th | SP Yu Darvish SD |
| 25 | 290th | C Alejandro Kirk Tor |
| 26 | 311th | OF Lars Nootbaar StL |
| 27 | 314th | SP Tomoyuki Sugano Bal |
| 28 | 335th | SP Reid Detmers LAA |
| 29 | 338th | SP Griffin Canning NYN |