| Round | Overall | Player |
|---|---|---|
| 1 | 12th | 1B Bryce Harper Phi |
| 2 | 13th | 3B Rafael Devers Bos |
| 3 | 36th | OF Mike Trout LAA |
| 4 | 37th | OF Brent Rooker Oak |
| 5 | 60th | 2B Jackson Holliday Bal |
| 6 | 61st | OF Riley Greene Det |
| 7 | 84th | SP Bryan Woo Sea |
| 8 | 85th | 1B Christian Encarnacion-Strand Cin |
| 9 | 108th | RP Felix Bautista Bal |
| 10 | 109th | RP Andres Munoz Sea |
| 11 | 132nd | 3B Josh Jung Tex |
| 12 | 133rd | SP Kodai Senga NYN |
| 13 | 156th | SP Nick Lodolo Cin |
| 14 | 157th | OF Evan Carter Tex |
| 15 | 180th | SP Walker Buehler Bos |
| 16 | 181st | SS Anthony Volpe NYA |
| 17 | 204th | SP Justin Verlander SF |
| 18 | 205th | SP Max Scherzer Tor |
| 19 | 228th | SS Jacob Wilson Oak |
| 20 | 229th | SP David Peterson NYN |
| 21 | 252nd | OF Andy Pages LAD |
| 22 | 253rd | SP Hayden Birdsong SF |
| 23 | 276th | 1B Ben Rice NYA |
| 24 | 277th | 2B Christian Moore LAA |
| 25 | 300th | 1B Jac Caglianone KC |
| 26 | 301st | C Carson Kelly ChN |
| 27 | 324th | OF Jordan Beck Col |
| 28 | 325th | C Keibert Ruiz Was |
| 29 | 348th | OF Mike Yastrzemski SF |