| Round | Overall | Player |
|---|---|---|
| 1 | 1st | DH Shohei Ohtani LAD |
| 2 | 24th | SS Trea Turner Phi |
| 3 | 25th | SP Paul Skenes Pit |
| 4 | 48th | 3B Junior Caminero TB |
| 5 | 49th | 2B Matt McLain Cin |
| 6 | 72nd | SP Garrett Crochet Bos |
| 7 | 73rd | 1B Josh Naylor Ari |
| 8 | 96th | SP Roki Sasaki LAD |
| 9 | 97th | OF Christian Yelich Mil |
| 10 | 120th | OF Tyler O'Neill Bal |
| 11 | 121st | RP Ryan Walker SF |
| 12 | 144th | RP Robert Suarez SD |
| 13 | 145th | OF Jurickson Profar Atl |
| 14 | 168th | SP Gavin Williams Cle |
| 15 | 169th | 1B Rhys Hoskins Mil |
| 16 | 192nd | OF Lane Thomas Cle |
| 17 | 193rd | SP Ryan Weathers Mia |
| 18 | 216th | SP Jared Jones Pit |
| 19 | 217th | 3B Brett Baty NYN |
| 20 | 240th | OF Matt Wallner Min |
| 21 | 241st | 1B Kyle Manzardo Cle |
| 22 | 264th | OF Joc Pederson Tex |
| 23 | 265th | RP Alexis Diaz Cin |
| 24 | 288th | SP Andrew Abbott Cin |
| 25 | 289th | SS Tyler Freeman Col |
| 26 | 312th | 1B Nick Kurtz Oak |
| 27 | 313th | C Drake Baldwin Atl |
| 28 | 336th | SP Tylor Megill NYN |
| 29 | 337th | C Patrick Bailey SF |