| Round | Overall | Player |
|---|---|---|
| 1 | 9th | OF Kyle Tucker ChN |
| 2 | 16th | OF Kyle Schwarber Phi |
| 3 | 33rd | C William Contreras Mil |
| 4 | 40th | 3B Mark Vientos NYN |
| 5 | 57th | 1B Triston Casas Bos |
| 6 | 64th | OF James Wood Was |
| 7 | 81st | SP Max Fried NYA |
| 8 | 88th | SP Bryce Miller Sea |
| 9 | 105th | SP Spencer Strider Atl |
| 10 | 112th | SP Hunter Greene Cin |
| 11 | 129th | 3B Royce Lewis Min |
| 12 | 136th | SP George Kirby Sea |
| 13 | 153rd | OF Tommy Edman LAD |
| 14 | 160th | SS Ezequiel Tovar Col |
| 15 | 177th | SP Shane Baz TB |
| 16 | 184th | 1B Spencer Torkelson Det |
| 17 | 201st | SP Michael Wacha KC |
| 18 | 208th | SP MacKenzie Gore Was |
| 19 | 225th | SS Masyn Winn StL |
| 20 | 232nd | OF Kerry Carpenter Det |
| 21 | 249th | SP Spencer Arrighetti Hou |
| 22 | 256th | SP Brandon Woodruff Mil |
| 23 | 273rd | OF Nolan Jones Cle |
| 24 | 280th | SP JP Sears Oak |
| 25 | 297th | OF Roman Anthony Bos |
| 26 | 304th | C Connor Wong Bos |
| 27 | 321st | RP Aroldis Chapman Bos |
| 28 | 328th | 3B Coby Mayo Bal |
| 29 | 345th | SP José Soriano LAA |