| Round | Overall | Player |
|---|---|---|
| 1 | 9th | OF Juan Soto NYN |
| 2 | 16th | OF Julio Rodriguez Sea |
| 3 | 33rd | OF Ronald Acuna Jr. Atl |
| 4 | 40th | OF Wyatt Langford Tex |
| 5 | 57th | OF Teoscar Hernández LAD |
| 6 | 64th | 1B Josh Naylor Ari |
| 7 | 81st | SP Max Fried NYA |
| 8 | 88th | 2B Matt McLain Cin |
| 9 | 105th | SP George Kirby Sea |
| 10 | 112th | SP Roki Sasaki LAD |
| 11 | 129th | SS Anthony Volpe NYA |
| 12 | 136th | SP Bryan Woo Sea |
| 13 | 153rd | OF Spencer Steer Cin |
| 14 | 160th | 3B Isaac Paredes Hou |
| 15 | 177th | 2B Nico Hoerner ChN |
| 16 | 184th | SP Grayson Rodriguez Bal |
| 17 | 201st | RP Carlos Estevez KC |
| 18 | 208th | 2B Luis Rengifo LAA |
| 19 | 225th | 2B Andrés Gimenez Tor |
| 20 | 232nd | SP Gavin Williams Cle |
| 21 | 249th | RP Liam Hendriks Bos |
| 22 | 256th | RP Kirby Yates LAD |
| 23 | 273rd | C Gabriel Moreno Ari |
| 24 | 280th | RP Bryan Abreu Hou |
| 25 | 297th | OF Garrett Mitchell Mil |
| 26 | 304th | 3B Dylan Moore Sea |
| 27 | 321st | SP Brayan Bello Bos |
| 28 | 328th | RP Camilo Doval SF |
| 29 | 345th | C Joey Bart Pit |