| Round | Overall | Player |
|---|---|---|
| 1 | 12th | 1B Vladimir Guerrero Jr. Tor |
| 2 | 13th | SS Francisco Lindor NYN |
| 3 | 36th | SP Dylan Cease SD |
| 4 | 37th | 2B Ketel Marte Ari |
| 5 | 60th | OF James Wood Was |
| 6 | 61st | SP Aaron Nola Phi |
| 7 | 84th | OF Bryan Reynolds Pit |
| 8 | 85th | OF Ian Happ ChN |
| 9 | 108th | 3B Mark Vientos NYN |
| 10 | 109th | 1B Willson Contreras StL |
| 11 | 132nd | RP Jeff Hoffman Tor |
| 12 | 133rd | SP Reynaldo Lopez Atl |
| 13 | 156th | SP Yusei Kikuchi LAA |
| 14 | 157th | SP Clay Holmes NYN |
| 15 | 180th | SP Brandon Pfaadt Ari |
| 16 | 181st | OF Colton Cowser Bal |
| 17 | 204th | SP Nick Lodolo Cin |
| 18 | 205th | OF Lane Thomas Cle |
| 19 | 228th | OF Heliot Ramos SF |
| 20 | 229th | 2B Bryson Stott Phi |
| 21 | 252nd | 2B Zack Gelof Oak |
| 22 | 253rd | OF Matt Wallner Min |
| 23 | 276th | 1B Carlos Santana Cle |
| 24 | 277th | OF Byron Buxton Min |
| 25 | 300th | OF Brandon Marsh Phi |
| 26 | 301st | OF Michael Conforto LAD |
| 27 | 324th | OF Jordan Walker StL |
| 28 | 325th | 1B Jeimer Candelario Cin |
| 29 | 348th | SP Ryan Weathers Mia |