| Week | Add | Drop |
| Week 2 |
Round 1: SP Brady Singer - KC Round 2: SP Cody Bradford - Tex |
Round 1: 1B Kris Bryant - Col |
| Week 3 |
Round 1: SP Colin Rea - Mil Round 2: OF Starling Marte - NYN | |
| Week 4 |
Round 1: SP José Butto - NYN Round 2: RP Tanner Scott - SD |
Round 1: 2B Whit Merrifield - Atl Round 2: SP Josiah Gray - Was |
| Week 5 |
Round 1: OF Pete Crow-Armstrong - ChN Round 2: SP Graham Ashcraft - Cin |
Round 1: SP J.P. France - Hou Round 2: SP Eduardo Rodriguez - Ari |
| Week 6 |
Round 1: OF Trevor Larnach - Min Round 2: SS Marcelo Mayer - Bos |
Round 1: OF Nolan Jones - Col Round 2: 1B Joshua Bell - Ari |
| Week 7 |
Round 1: OF Jonny DeLuca - TB Round 2: SS Colson Montgomery - ChA |
Round 1: SP Sandy Alcantara - Mia Round 2: RP Tanner Scott - SD |
| Week 8 |
Round 1: 3B Mark Vientos - NYN Round 2: 3B Brady House - Was |
Round 1: OF Trevor Larnach - Min Round 2: SP José Butto - NYN |
| Week 9 |
Round 1: OF Heliot Ramos - SF Round 1: OF Heliot Ramos - SF Round 2: SP Ben Lively - Cle |
Round 1: SP Cody Bradford - Tex Round 1: SP Cody Bradford - Tex Round 2: C Elias Diaz - SD |
| Week 11 |
Round 2: 3B Abraham Toro - Oak | |
| Week 14 |
Round 1: OF Roman Anthony - Bos | |
| Week 16 |
Round 1: C Samuel Basallo - Bal Round 2: SS Max Muncy - Oak |
Round 1: SP Triston McKenzie - Cle Round 2: OF Jonny DeLuca - TB |
| Week 22 |
Round 2: 1B Jeimer Candelario - Cin |
| 1st Team | 2nd Team |
| Pre-Season | |
| Cleveland Buckeyes | Nolan Ryan |
|
OF
Brent Rooker
Oak |
|
| Week 8 | |
| Cleveland Buckeyes | Tuesday Afternoon |
|
OF
George Springer
Tor SP Colin Rea Mil SP Dustin May LAD SS Oneil Cruz Pit OF Evan Carter Tex |
SP
Aaron Nola
Phi C Elias Diaz Col 1B Jeimer Candelario Cin SP Cole Ragans KC SP Tarik Skubal Det |