| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Chad Tracy  Round 2: OF Nick Swisher  | |
| Week 1 |
Round 1: OF Adam Lind  |
Round 1: 3B Brandon Wood  |
| Week 3 |
Round 1: 2B Gordon Beckham  |
Round 1: RP J.J. Putz |
| Week 4 |
Round 1: 2B Julio Lugo  Round 2: C Jason Jaramillo  |
Round 1: 3B Chase Headley  Round 2: OF Adam Lind Round 2: OF Nick Swisher |
| Week 5 |
Round 1: 3B Joe Crede  Round 2: 3B Andy LaRoche |
Round 1: 3B Chad Tracy  Round 2: 3B Joe Crede |
| Week 6 |
Round 1: 3B Joe Crede Round 2: C Carlos Ruiz  |
Round 1: 3B Andy LaRoche Round 2: C Jason Jaramillo |
| Week 8 |
Round 1: SP Brad Penny  |
Round 1: SP Brett Myers  |
| Week 9 |
Round 1: 1B Travis Ishikawa  Round 2: 2B Luis Castillo  |
Round 2: 1B Casey Kotchman |
| Week 10 |
Round 1: OF Chris Coghlan Round 2: 1B Ty Wigginton  |
Round 1: 2B Julio Lugo Round 2: 1B Travis Ishikawa |
| Week 12 |
Round 1: OF Chris Duncan  |
Round 1: 1B Ty Wigginton Round 2: DH Hideki Matsui Round 2: 2B Kelly Johnson |
| Week 16 |
Round 1: SS Erick Aybar Round 2: OF Eric Hinske |
Round 1: OF Chris Duncan Round 2: 3B Joe Crede |
| Week 17 |
Round 1: 2B Julio Lugo |
Round 1: SP Aaron Harang  |
| Week 18 |
Round 1: OF Marlon Byrd  Round 2: SS Craig Counsell  |
Round 1: SP John Smoltz Round 2: 2B Luis Castillo |
| Week 19 |
Round 1: SP Hiroki Kuroda  Round 2: 3B Garrett Atkins  |
Round 1: 3B Brandon Inge  Round 2: OF Eric Hinske |
| Week 21 |
Round 1: OF Mike Cameron Round 2: SP John Smoltz |
Round 2: SP Brad Penny |
| Week 23 |
Round 1: OF Carlos Gonzalez Round 2: SP Brett Myers |
Round 1: SP John Smoltz Round 2: SS Craig Counsell |
| 1st Team | 2nd Team | Votes |
| Week 4 | ||
| Buffalo Horseheads | Dave's Destroyers | Decision |
|
C
Jorge Posada
1B Todd Helton SP Brad Penny SS J.J. Hardy |
SP
Brett Myers
1B Casey Kotchman  SP Philip Hughes 1B Matt LaPorta  |
Approved 23-1. See Breakdown |