| Week | Add | Drop |
| Week 1 |
Round 1: OF Micahel Taylor - KC Round 2: SP Carlos Rodon - ChA | |
| Week 2 |
Round 1: C Tucker Barnhart - Cin | |
| Week 3 |
Round 1: 3B Jed Lowrie - Oak Round 2: SP Joe Ross - Was |
Round 1: OF Kike Hernandez - Bos Round 2: RP Jordan Romano - Tor |
| Week 4 |
Round 1: SP Josh Fleming - TB | |
| Week 5 |
Round 1: OF Tyler O'Neill - StL Round 2: RP Huascar Ynoa - Atl |
Round 1: SP Ryan Yarbrough - TB Round 2: OF David Dahl - Tex |
| Week 6 |
Round 1: C Yan Gomes - ChN |
Round 1: C Danny Jansen - Tor |
| Week 7 |
Round 1: 1B Will Craig - Pit Round 2: SS Willi Castro - Det |
Round 2: SS Luis Urias - Mil |
| Week 8 |
Round 1: OF Danny Santana - Bos Round 2: SS Taylor Walls - TB |
Round 1: C Sam Huff - Tex Round 2: 1B Will Craig - Pit |
| Week 9 |
Round 1: RP Ryan Weathers - SD |
Round 1: OF Nick Senzel - Cin |
| Week 10 |
Round 1: SP Alexander Cobb - LAA Round 2: RP Lucas Sims - Cin |
Round 1: OF Danny Santana - Bos Round 2: RP Huascar Ynoa - Atl |
| Week 11 |
Round 1: C Ryan Jeffers - Min Round 2: OF Billy McKinney - LAD |
Round 1: SP Joe Ross - Was Round 2: C Yan Gomes - Oak |
| Week 12 |
Round 1: OF Tony Kemp - Oak Round 2: SP Patrick Sandoval - LAA |
Round 1: RP Ryan Weathers - SD Round 2: OF Billy McKinney - Mil |
| Week 13 |
Round 1: SP Drew Smyly - ChN Round 2: 1B Garrett Cooper - Mia |
Round 1: SS Taylor Walls - TB Round 2: RP Lucas Sims - Cin |
| Week 14 |
Round 1: 3B Jake Burger - ChA |
Round 1: SP Andrew Heaney - LAA |
| Week 17 |
Round 1: C Daulton Varsho - Ari Round 2: OF Brian Anderson - Mia |
Round 2: OF Tony Kemp - Oak |
| Week 18 |
Round 1: SP Tanner Houck - Bos Round 2: SS Owen Miller - Cle |
Round 1: 3B Jake Burger - ChA Round 2: 1B Garrett Cooper - Mia |
| Week 19 |
Round 1: 1B Rowdy Tellez - Mil |
Round 1: SS Willi Castro - Det |
| Week 20 |
Round 1: OF Anthony Santander - Bal Round 2: RP Alex Colome - Col |
Round 1: SP Tanner Houck - Bos Round 2: SP Alexander Cobb - LAA |
| Week 22 |
Round 2: SP Alec Mills - ChN |
Round 2: SP Patrick Sandoval - LAA |
| 1st Team | 2nd Team |
| Pre-Season | |
| The Green Machine | Great Lakes Loons |
|
3B
Nolan Arenado
StL SS J.P. Crawford Sea |
3B
Manny Machado
SD C Omar Narváez Mil |
| Week 14 | |
| The Green Machine | Cuban Stars |
|
OF
Kyle Lewis
Sea SS Jeter Downs Bos |
SP
Dallas Keuchel
ChA SP Anthony DeSclafani SF |