| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Elehuris Montero - Col Round 2: 2B Whit Merrifield - Phi |
Round 1: 3B D.J. LeMahieu - NYA |
| Week 1 |
Round 1: RP Michael Kopech - ChA Round 2: RP Daniel Hudson - LAD |
Round 2: RP Alex Lange - Det |
| Week 2 |
Round 1: 3B Trey Lipscomb - Was Round 2: RP David Robertson - Tex |
Round 1: 3B Elehuris Montero - Col Round 2: SP Jackson Jobe - Det Round 2: 2B Whit Merrifield - Phi |
| Week 3 |
Round 1: SP Yariel Rodriguez - Tor |
Round 1: RP Daniel Hudson - LAD |
| Week 4 |
Round 1: SP Kyle Gibson - StL Round 2: RP Abner Uribe - Mil |
Round 1: SP Kyle Hendricks - ChN |
| Week 5 |
Round 1: RP Orion Kerkering - Phi Round 2: RP Yennier Cano - Bal |
Round 2: SS Marco Luciano - SF Round 2: RP David Robertson - Tex Round 2: RP Abner Uribe - Mil |
| Week 6 |
Round 1: OF Jurickson Profar - SD Round 2: C Bo Naylor - Cle |
Round 1: 2B Jeff McNeil - NYN |
| 1st Team | 2nd Team |
| Pre-Season | |
| Horseheads Buffalos | Knoxville Giants |
|
SS
Willy Adames
Mil |
Round 11, 5th Pick (2B Jordan Westburg Bal) |
| Pre-Season | |
| Horseheads Buffalos | Savannah Sand Gnats |
|
RP
Alexis Diaz
Cin |
Round 11, 6th Pick (SP Luis Severino NYN) |
| Week 4 | |
| Horseheads Buffalos | bottom of the pack 20 |
|
OF
Teoscar Hernández
LAD SP Dylan Cease SD 1B Spencer Torkelson Det 2B Jordan Westburg Bal |
SP
Kyle Hendricks
ChN 2B Jeff McNeil NYN OF Corbin Carroll Ari RP Jason Foley Det |