| Week | Add | Drop |
| Pre-Season |
Round 1: RP Ryan Pressly - Hou Round 2: OF Walker Jenkins - Min Round A: OF Roman Anthony - Bos |
Round B: SP Pat Corbin - Was |
| Week 1 |
Round 1: SS Masyn Winn - StL Round 2: SP Dane Dunning - Tex | |
| Week 2 |
Round 1: SP Matt Manning - Det Round 2: SP Martin Perez - Pit |
Round 2: RP Ryan Pressly - Hou |
| Week 3 |
Round 1: C Ivan Herrera - StL |
Round 1: OF Roman Anthony - Bos |
| Week 4 |
Round 1: OF Jesse Winker - Was Round 2: SP José Butto - NYN |
Round 1: SP Ricky Tiedemann - Tor Round 2: C Ivan Herrera - StL |
| Week 5 |
Round 1: RP Joel Payamps - Mil Round 2: 2B Rob Refsnyder - Bos |
Round 1: 1B Jose Abreu - Hou Round 2: OF Walker Jenkins - Min |
| Week 6 |
Round 1: SP Trevor Williams - Was Round 2: OF Wenceel Perez - Det |
Round 1: RP Joel Payamps - Mil Round 2: SP Matt Manning - Det |
| Week 7 |
Round 1: OF Jonny DeLuca - TB Round 2: SP Brandon Pfaadt - Ari |
Round 1: OF Chase DeLauter - Cle Round 2: 3B Ke'Bryan Hayes - Pit |
| 1st Team | 2nd Team |
| Pre-Season | |
| Lexington Wildcats | Nashville Stars |
|
Round 3, 1st Pick (SP Kodai Senga NYN) Round 1, 12th Pick (SP Freddy Peralta Mil) Round 17, 12th Pick (SP Reese Olson Det) Round 18, 12th Pick (RP James McArthur KC) Round 19, 12th Pick (RP Michael Kopech ChA) |
1B
Bryce Harper
Phi Round 5, 6th Pick (SP Nathan Eovaldi Tex) |
| Pre-Season | |
| Lexington Wildcats | Nashville Stars |
|
SP
Aaron Nola
Phi |
Round 3, 8th Pick (SP Jesus Luzardo Mia) |
| Pre-Season | |
| Lexington Wildcats | Rain Delay |
|
RP
Emmanuel Clase
Cle |
Round 4, 10th Pick (3B Ke'Bryan Hayes Pit) |
| Pre-Season | |
| Lexington Wildcats | Sugar Land Space Cowboys |
|
SP
Chris Sale
Atl |
Round 8, 1st Pick (RP Craig Kimbrel Bal) |
| Pre-Season | |
| Lexington Wildcats | Nashville Stars |
|
SP
Logan Webb
SF |
RP
Emmanuel Clase
Cle Round 4, 8th Pick (RP Paul Sewald Ari) |
| Pre-Season | |
| Lexington Wildcats | Sugar Land Space Cowboys |
|
Round 4, 12th Pick (1B Andrew Vaughn ChA) |
C
Gary Sanchez
Mil |
| Pre-Season | |
| Lexington Wildcats | Sugar Land Space Cowboys |
|
Round 6, 12th Pick (3B Eugenio Suarez Ari) |
2B
Thairo Estrada
SF |
| Pre-Season | |
| Lexington Wildcats | Rain Delay |
|
Round 8, 12th Pick (OF Steven Kwan Cle) |
RP
Jordan Romano
Tor |
| Pre-Season | |
| Lexington Wildcats | Nashville Stars |
|
Round 15, 12th Pick (2B Jeff McNeil NYN) |
Round 16, 8th Pick (SP Ricky Tiedemann Tor) Round 17, 8th Pick (OF Sal Frelick Mil) |
| Pre-Season | |
| Lexington Wildcats | Sugar Land Space Cowboys |
|
RP
Ryan Pressly
Hou RP Raisel Iglesias Atl 2B Zack Gelof Oak |
Round 3, 1st Pick (SP Kodai Senga NYN) Round 5, 1st Pick (SP Justin Verlander Hou) Round 7, 1st Pick (SP Kyle Bradish Bal) |