| Week | Add | Drop |
| Pre-Season |
Round 2: SP Clarke Schmidt - NYA | |
| Week 2 |
Round 1: SP Tyler Anderson - LAA | |
| Week 4 |
Round 1: 1B Ryan O'Hearn - Bal |
Round 1: OF Max Kepler - Min |
| Week 5 |
Round 1: OF Jake Fraley - Cin Round 2: SP Keaton Winn - SF |
Round 1: 1B Andrew Vaughn - ChA Round 2: SP Taijuan Walker - Phi |
| Week 6 |
Round 1: 1B Tyler Nevin - Oak |
Round 1: SP Wade Miley - Mil |
| Week 7 |
Round 2: 3B Brett Harris - Oak |
Round 2: 2B Cavan Biggio - Atl |
| Week 8 |
Round 1: 2B Michael Massey - KC Round 2: 3B Dylan Moore - Sea |
Round 1: OF TJ Friedl - Cin Round 2: 3B Jared Triolo - Pit |
| Week 9 |
Round 1: SP Taijuan Walker - Phi Round 1: SP Taijuan Walker - Phi Round 2: OF Gavin Sheets - ChA |
Round 2: 1B Tyler Nevin - Oak |
| Week 10 |
Round 1: OF Andrew McCutchen - Pit Round 2: SP Simeon Woods Richardson - Min |
Round 1: OF Chas McCormick - Hou Round 2: OF Jake Fraley - Cin |
| Week 11 |
Round 1: 1B Ty France - Cin Round 2: SP Joey Estes - Oak |
Round 1: 1B Joey Meneses - Was Round 2: SP Keaton Winn - SF |
| Week 12 |
Round 1: SP Cal Quantrill - Col |
Round 1: 1B Ty France - Cin |
| Week 14 |
Round 1: SP David Peterson - NYN Round 2: OF Joc Pederson - Ari |
Round 1: SP Taijuan Walker - Phi Round 2: SP Kyle Bradish - Bal |
| Week 16 |
Round 1: SP José Butto - NYN |
Round 1: SP Clarke Schmidt - NYA |
| Week 18 |
Round 1: 1B Joshua Bell - Ari Round 2: OF Richie Palacios - TB |
Round 1: SP José Butto - NYN Round 2: OF Gavin Sheets - ChA |
| Week 19 |
Round 1: SP Ryne Nelson - Ari |
Round 1: SP Simeon Woods Richardson - Min |
| Week 22 |
Round 1: OF Trevor Larnach - Min Round 2: 3B Jonah Bride - Mia |
Round 1: OF Richie Palacios - TB Round 2: SP Jordan Montgomery - Ari |
| 1st Team | 2nd Team |