| Week | Add | Drop |
| Pre-Season |
Round 1: OF Adam Duvall - Atl Round 2: OF Mickey Moniak - LAA Round A: C Ethan Salas - SD |
Round 1: C Freddy Fermin - KC Round A: C Luis Campusano - SD |
| Week 2 |
Round 1: 1B Alex Kirilloff - Min Round 2: SP Zack Littell - TB | |
| Week 3 |
Round 2: RP Michael Kopech - ChA |
Round 2: 3B Yoan Moncada - ChA |
| Week 4 |
Round 1: RP Kirby Yates - Tex |
Round 1: SP Eury Perez - Mia |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos Round 2: OF Jo Adell - LAA |
Round 1: RP Jose Leclerc - Tex Round 2: OF Mickey Moniak - LAA |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: SP John Means - Bal |
Round 1: RP Griffin Jax - Min Round 2: OF Adam Duvall - Atl |
| 1st Team | 2nd Team |
| Pre-Season | |
| Louisville Bats | NYSE: AAPL |
|
OF
Jazz Chisholm
Mia Round 5, 4th Pick (1B Jeimer Candelario Cin) |
OF
Byron Buxton
Min SP Shane Bieber Cle |
| Pre-Season | |
| Louisville Bats | Horseheads Buffalos |
|
SP
Gerrit Cole
NYA |
1B
Triston Casas
Bos 3B Noelvi Marte Cin SS Ezequiel Tovar Col SS Jordan Lawlar Ari Round 2, 11th Pick (SP Gavin Williams Cle) |
| Pre-Season | |
| Louisville Bats | Got Heeeem |
|
2B
Nico Hoerner
ChN |
Round 6, 7th Pick (OF Giancarlo Stanton NYA) |
| Week 3 | |
| Louisville Bats | The Shogun of Harlem |
|
SP
Logan Gilbert
Sea |
SP
Triston McKenzie
Cle |
| Week 3 | |
| Louisville Bats | Whiz Kids |
|
OF
Giancarlo Stanton
NYA RP Raisel Iglesias Atl |
SP
Max Meyer
Mia OF Joey Loperfido Hou |