| Week | Add | Drop |
| Week 1 |
Round 1: SP Chris Flexen - Sea Round 2: OF Akil Baddoo - Det |
Round 2: 3B Carter Kieboom - Was |
| Week 2 |
Round 1: SP Carlos Rodon - ChA Round 2: SP Steven Matz - StL |
Round 1: SP James Paxton - Sea Round 2: RP Anthony Bass - Mia |
| Week 4 |
Round 1: SP Domingo German - NYA |
Round 1: C Sean Murphy - Oak Round 2: SP Drew Smyly - Atl Round 2: OF Tommy Pham - SD |
| Week 5 |
Round 1: RP Huascar Ynoa - Atl |
Round 1: SS Miguel Rojas - Mia |
| Week 6 |
Round 1: RP Jake Diekman - Oak |
Round 1: OF Akil Baddoo - Det |
| Week 7 |
Round 1: SP Corey Kluber - NYA Round 2: OF Estevan Florial - NYA |
Round 1: SS Jorge Polanco - Min Round 2: 1B Seth Beer - Ari |
| Week 8 |
Round 1: OF Kyle Schwarber - Phi |
Round 1: RP Jordan Romano - Tor |
| Week 9 |
Round 1: RP James Kaprielian - Oak Round 2: SS Freddy Galvis - Bal |
Round 1: SP Corey Kluber - NYA Round 2: SS Andrés Gimenez - Cle |
| Week 10 |
Round 1: 3B Patrick Wisdom - ChN Round 2: SS Freddy Galvis - Bal |
Round 1: SP Robbie Ray - Tor Round 2: RP James Kaprielian - Oak |
| Week 11 |
Round 1: RP Diego Castillo - Sea Round 2: 3B Dylan Moore - Sea |
Round 1: RP Jake Diekman - Oak Round 2: OF Kyle Schwarber - Was |
| Week 12 |
Round 1: OF Kyle Schwarber - Phi Round 2: SP Erick Fedde - Was |
Round 1: SP Dane Dunning - Tex Round 2: OF Estevan Florial - NYA |
| Week 14 |
Round 1: 1B Gavin Sheets - ChA |
Round 1: SP Nate Pearson - Tor |
| Week 15 |
Round 1: SP Kwang-Hyun Kim - StL Round 2: OF Drew Waters - Atl |
Round 2: SP Steven Matz - Tor |
| Week 17 |
Round 1: OF Estevan Florial - NYA Round 2: SP Touki Toussaint - Atl |
Round 1: 3B Dylan Moore - Sea Round 2: 1B Gavin Sheets - ChA |
| Week 18 |
Round 1: 3B Dylan Moore - Sea Round 2: SP Jaime Barria - LAA |
Round 1: SP Domingo German - NYA Round 2: SP Kwang-Hyun Kim - StL |
| Week 19 |
Round 1: C Yasmani Grandal - ChA Round 2: SP Daulton Jefferies - Oak |
Round 1: 3B Dylan Moore - Sea Round 2: SP Touki Toussaint - Atl |
| Week 20 |
Round 1: OF Frank Schwindel - ChN Round 2: SP Dane Dunning - Tex |
Round 1: SS J.P. Crawford - Sea Round 2: RP Diego Castillo - Sea |
| Week 22 |
Round 1: RP Edward Cabrera - Mia |
Round 1: SP Jaime Barria - LAA |
| 1st Team | 2nd Team |
| Pre-Season | |
| Minneapolis Keystones | Fightin Phils |
|
RP
Kenley Jansen
LAD OF Kole Calhoun Ari |
SP
Luis Severino
NYA SP Framber Valdez Hou |
| Pre-Season | |
| Minneapolis Keystones | NYSE: AVGO |
|
SP
Zack Greinke
Hou SP Gerrit Cole NYA |
OF
Nick Castellanos
Cin SS Javier Baez ChN OF Randy Arozarena TB |
| Week 10 | |
| Minneapolis Keystones | NYSE: AVGO |
|
3B
Jose Ramirez
Cle OF Jarred Kelenic Sea |
SP
Gerrit Cole
NYA OF Eddie Rosario Atl 3B Austin Riley Atl |
| Week 13 | |
| Minneapolis Keystones | The Shogun of Harlem |
|
OF
Franmil Reyes
Cle |
SP
Luis Castillo
Cin 2B Vidal Brujan TB |
| Week 14 | |
| Minneapolis Keystones | Santa’s Stars |
|
3B
Austin Riley
Atl 2B Nick Madrigal ChA |
SS
J.P. Crawford
Sea 2B Chris Taylor LAD |