| Week | Add | Drop |
| Pre-Season |
Round 2: SP Jair Jurrjens - Atl | |
| Week 1 |
Round 1: OF Nate McLouth - Pit |
Round 1: OF Jonny Gomes - Cin |
| Week 2 |
Round 2: 3B Brandon Inge - Det |
Round 2: OF Juan Rivera - LAA |
| Week 3 |
Round 1: SP Rafael Betancourt - Cle Round 2: 2B Mark DeRosa - ChN |
Round 2: 2B Tadahito Iguchi - SD |
| Week 4 |
Round 1: RP Brian Fuentes - Col |
Round 1: SS Alexei Ramirez - ChA |
| Week 5 |
Round 2: C Yadier Molina - StL |
Round 2: RP Jeremiah Accardo - Tor Round 2: C John Buck - KC |
| Week 6 |
Round 2: OF Jose Guillen - KC | |
| Week 7 |
Round 1: SS Maicer Izturis - LAA |
Round 1: SP Rafael Betancourt - Cle |
| Week 9 |
Round 1: RP Salomon Torres - Mil Round 2: SS Mike Aviles - KC | |
| Week 10 |
Round 2: C Jeff Clement - Sea |
Round 2: SS Julio Lugo - Bos |
| Week 12 |
Round 1: SP Kenny Rogers - Det Round 2: OF Elijah Dukes - Was |
Round 1: RP Eric Gagne - Mil Round 2: C Yadier Molina - StL |
| Week 13 |
Round 1: SP Nate Robertson - Det Round 2: 2B Jeff Baker - Col |
Round 1: SP Chris Young - SD Round 2: 3B Ty Wigginton - Bal |
| Week 15 |
Round 1: SP Dave Bush - Mil |
Round 1: OF Elijah Dukes - Was |
| Week 17 |
Round 1: C Yadier Molina - StL |
Round 1: C Jeff Clement - Sea |
| Week 18 |
Round 1: 2B Omar Infante - Atl Round 2: OF Elijah Dukes - Was |
Round 1: SS Khalil Greene - SD Round 2: SP Dave Bush - Mil |
| Week 19 |
Round 1: OF Marlon Byrd - Tex |
Round 1: OF Elijah Dukes - Was Round 2: SP Nate Robertson - Det |
| Week 21 |
Round 1: OF Denard Span - Min Round 2: 1B Nomar Garciaparra - LAD |
Round 2: 2B Jeff Baker - Col |
| 1st Team | 2nd Team | Votes |
| Pre-Season | ||
| NYSE: AVGO | Acuna Machado | Decision |
|
SS
Derek Jeter
NYA |
1B
Derrek Lee
ChN |
Approved 24-0. See Breakdown |