| Week | Add | Drop |
| Week 1 |
Round 1: SP Ryan Yarbrough - TB Round 2: OF Nomar Mazara - Det | |
| Week 2 |
Round 1: SP Dane Dunning - Tex Round 2: 1B Darin Ruf - SF |
Round 2: OF Nomar Mazara - Det |
| Week 3 |
Round 1: SP Kendall Graveman - Hou |
Round 1: RP Anthony Bass - Mia |
| Week 6 |
Round 1: RP James Karinchak - Cle Round 2: C Stephen Vogt - Oak |
Round 1: SP Ryan Yarbrough - TB Round 2: C Danny Jansen - Tor |
| Week 7 |
Round 1: SP Carlos Martinez - StL Round 2: SP Adbert Alzolay - ChN |
Round 1: C Luis Campusano - SD Round 2: SP Trevor Williams - ChN |
| Week 8 |
Round 1: SP Garrett Richards - Bos Round 2: 2B Cesar Hernández - Was |
Round 1: RP James Karinchak - Cle Round 2: 2B David Bote - ChN |
| Week 9 |
Round 1: RP John Gant - StL Round 2: RP Jake Diekman - Oak | |
| Week 11 |
Round 1: RP Lou Trivino - Oak Round 2: OF Hunter Renfroe - Mil |
Round 1: RP Jake Diekman - Oak Round 2: SP David Peterson - NYN |
| Week 12 |
Round 1: SP Tarik Skubal - Det Round 2: OF Chas McCormick - Hou |
Round 1: SP Brady Singer - KC Round 2: SP Kendall Graveman - Sea |
| Week 13 |
Round 1: OF Daz Cameron - Det Round 2: C Tucker Barnhart - Cin |
Round 1: C Stephen Vogt - Ari Round 2: SP Dane Dunning - Tex |
| Week 14 |
Round 2: SP Cole Irvin - Oak |
Round 2: SP Garrett Richards - Bos |
| Week 17 |
Round 1: RP Austin Gomber - Col Round 2: SP Ryan Yarbrough - TB |
Round 1: RP John Gant - StL Round 2: SP Carlos Martinez - StL |
| Week 18 |
Round 1: SP Joe Ross - Was Round 2: OF A.J. Pollock - LAD |
Round 1: OF Daz Cameron - Det Round 2: OF Chas McCormick - Hou |
| Week 20 |
Round 1: C Tyler Stephenson - Cin Round 2: SP Drew Smyly - ChN |
Round 1: SP Ryan Yarbrough - TB Round 2: OF Nick Senzel - Cin |
| 1st Team | 2nd Team |