| Week | Add | Drop |
| Pre-Season |
Round 1: 2B Luis Rengifo - LAA Round 2: RP Trevor Megill - Mil Round A: C Gabriel Moreno - Ari |
Round A: SP James Paxton - Bos |
| Week 1 |
Round 1: OF Steven Kwan - Cle Round 2: 1B Jared Walsh - ChA | |
| Week 2 |
Round 1: SP Javier Assad - ChN | |
| Week 3 |
Round 1: SP Reynaldo Lopez - Atl Round 2: RP Kevin Ginkel - Ari |
Round 1: RP Trevor Megill - Mil Round 2: 2B Luis Rengifo - LAA |
| Week 4 |
Round 1: SP Mike Lorenzen - KC Round 2: C Ryan Jeffers - Min |
Round 1: OF Parker Meadows - Det Round 2: SP Matt Manning - Det |
| Week 5 |
Round 1: SP Bryce Elder - Atl Round 2: OF Mark Canha - SF |
Round 2: 1B Jared Walsh - ChA Round 2: OF Sal Frelick - Mil |
| Week 6 |
Round 1: OF Jo Adell - LAA Round 2: SP Landon Knack - LAD |
Round 1: 3B Anthony Rendon - LAA Round 2: SP Brandon Pfaadt - Ari |
| Week 7 |
Round 1: OF Bryan De La Cruz - Pit Round 2: OF Jonny DeLuca - TB |
Round 1: RP Adbert Alzolay - ChN Round 2: SP Landon Knack - LAD |
| Week 8 |
Round 1: SP Cole Irvin - Min Round 2: RP José Soriano - LAA |
Round 1: C Keibert Ruiz - Was Round 2: RP Kevin Ginkel - Ari |
| Week 9 |
Round 1: OF Jake Meyers - Hou Round 1: OF Jake Meyers - Hou Round 2: SP Brandon Pfaadt - Ari |
Round 1: OF Masataka Yoshida - Bos Round 1: OF Masataka Yoshida - Bos Round 2: SP Bryce Elder - Atl |
| Week 10 |
Round 1: 2B Michael Massey - KC Round 2: OF Andrew McCutchen - Pit |
Round 1: SP Graham Ashcraft - Cin Round 2: OF Cedric Mullins II - Bal |
| Week 11 |
Round 1: SP Matt Waldron - SD Round 2: SS Paul DeJong - KC |
Round 1: OF Jonny DeLuca - TB Round 2: OF Jake Meyers - Hou |
| Week 12 |
Round 1: SS Brooks Lee - Min Round 2: 1B Deyvison De Los Santos - Mia |
Round 1: OF Andrew McCutchen - Pit Round 2: SP JP Sears - Oak |
| Week 13 |
Round 1: 1B Michael Toglia - Col Round 2: 3B Daniel Schneemann - Cle |
Round 2: SS Orlando Arcia - Atl |
| Week 14 |
Round 1: C Bo Naylor - Cle Round 2: 2B Brendan Rodgers - Col |
Round 1: SP Javier Assad - ChN Round 2: 2B Thairo Estrada - SF |
| Week 15 |
Round 1: SP Josh Winckowski - Bos Round 2: 2B Miguel Vargas - ChA |
Round 1: SP Cole Irvin - Min Round 2: OF Jo Adell - LAA |
| Week 16 |
Round 1: OF Charlie Condon - Col Round 2: OF Lawrence Butler - Oak |
Round 1: OF Bryan De La Cruz - Pit Round 2: OF Mark Canha - SF |
| Week 18 |
Round 1: OF Tyler Fitzgerald - SF Round 2: SP Spencer Schwellenbach - Atl |
Round 1: 3B Daniel Schneemann - Cle Round 2: SS Paul DeJong - KC |
| Week 19 |
Round 2: C Tyler Stephenson - Cin |
Round 2: 2B Michael Massey - KC |
| Week 20 |
Round 1: OF Jake McCarthy - Ari Round 2: SP Gavin Williams - Cle |
Round 1: SP Josh Winckowski - Bos Round 2: SP Mike Lorenzen - KC |
| Week 22 |
Round 2: C Keibert Ruiz - Was |
Round 2: C Ryan Jeffers - Min |
| 1st Team | 2nd Team |
| Pre-Season | |
| NYSE: SNA | Wisdom |
|
SP
Jeffrey Springs
TB |
|
| Pre-Season | |
| NYSE: SNA | Spoilers |
|
OF
Eloy Jimenez
Bal SP Luis Castillo Sea |
|
| Pre-Season | |
| NYSE: SNA | No Clue |
|
2B
Jose Altuve
Hou |
|
| Pre-Season | |
| NYSE: SNA | Wisdom |
| Week 11 | |
| NYSE: SNA | “1969” |
|
2B
Jose Altuve
Hou SS Corey Seager Tex RP Raisel Iglesias Atl SP Reynaldo Lopez Atl SP George Kirby Sea Round 10, 3rd Pick (SP Ben Lively Cle) Round 11, 3rd Pick (1B Luis Arraez SD) |
SS
Trea Turner
Phi 2B Luis Garcia Was RP Camilo Doval SF 3B Josh Jung Tex SP JP Sears Oak Round 4, 12th Pick (OF Jurickson Profar Atl) Round 6, 12th Pick (SP Jose Berrios Tor) |
| Week 13 | |
| NYSE: SNA | Spoilers |
|
OF
Steven Kwan
Cle |
Round 4, 2nd Pick (3B Alec Bohm Phi) |