| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Bill Hall - Mil | |
| Week 1 |
Round 1: OF Marlon Byrd - Tex Round 2: SP Ricky Romero - Tor |
Round 2: OF Jerry Hairston Jr. - NYA |
| Week 2 |
Round 1: SP Zach Duke - Pit Round 2: 2B David Eckstein - SD |
Round 1: OF Delmon Young - Min Round 2: SS Maicer Izturis - LAA |
| Week 3 |
Round 1: SP Dave Bush - Mil Round 2: SP Ross Ohlendorf - Pit |
Round 2: SP Bartolo Colon - ChA |
| Week 4 |
Round 1: SP Dallas Braden - Oak |
Round 2: 3B Kevin Kouzmanoff - Oak |
| Week 5 |
Round 1: SP Barry Zito - SF Round 2: OF Scott Hairston - Oak |
Round 2: SP John Smoltz - Hou Round 2: OF Eric Byrnes - Ari |
| Week 6 |
Round 1: SP Scott Downs - Tor Round 2: OF Jerry Hairston Jr. - NYA |
Round 1: OF Scott Hairston - SD Round 2: 2B David Eckstein - SD |
| Week 7 |
Round 1: OF Jeremy Hermida - Fla |
Round 1: OF Marlon Byrd - ChN |
| Week 8 |
Round 1: SP Brad Penny - Bos Round 2: OF Scott Hairston - Oak |
Round 1: SP Dave Bush - Mil Round 2: 1B Matt LaPorta - Cle |
| Week 9 |
Round 1: OF Chris Coghlan - Fla Round 2: SP Josh Outman - Oak |
Round 1: 3B Bill Hall - Mil Round 2: SP Barry Zito - SF |
| Week 10 |
Round 2: 3B Kevin Kouzmanoff - SD |
Round 2: OF Chris Coghlan - Fla Round 2: SP Brad Penny - StL |
| Week 11 |
Round 1: RP Huston Street - Col Round 2: SP Jeremy Guthrie - Bal |
Round 2: SP Josh Outman - Oak |
| Week 12 |
Round 1: SP Homer Bailey - Cin Round 2: OF Elijah Dukes - Was |
Round 1: SP Carl Pavano - Min Round 2: OF Jeremy Hermida - Bos |
| Week 13 |
Round 1: OF Ryan Church - Was Round 2: 2B Martin Prado - Atl |
Round 1: SP Homer Bailey - Cin Round 2: OF Elijah Dukes - Was |
| Week 14 |
Round 1: 3B Jake Fox - ChN |
Round 1: OF Ryan Church - Pit |
| Week 16 |
Round 1: SP Craig Stammen - Was | |
| Week 17 |
Round 1: SP David Hernández - Bal Round 2: SP C.J. Wilson - Tex |
Round 1: SP Scott Downs - Tor |
| Week 18 |
Round 1: SP Barry Zito - SF Round 2: SP Braden Looper - Mil |
Round 1: SP Glen Perkins - Min Round 2: SP C.J. Wilson - Tex Round 2: DH Gary Sheffield - NYN Round 2: 1B Mike Jacobs - KC Round 2: SP Craig Stammen - Was |
| Week 19 |
Round 1: SP Gio Gonzalez - Oak | |
| Week 21 |
Round 1: SP Doug Fister - Sea |
Round 1: SP David Hernández - Bal |
| 1st Team | 2nd Team | Votes |
| Week 3 | ||
| Galatians | Savannah Bananas | Decision |
|
RP
Joe Nathan
Min C Russell Martin LAD SP Clayton Kershaw LAD |
C
Ben Molina
SF OF Matt Kemp LAD |
Approved 17-9. See Breakdown |
| Week 6 | ||
| Galatians | Michigan Maulers 2 | Decision |
|
3B
Alex Rodriguez
NYA OF Chris Duncan StL SP Ross Ohlendorf Pit SP Dallas Braden Oak |
SP
John Lackey
LAA 1B Mike Jacobs KC 3B Ryan Zimmerman Was 1B Matt LaPorta Cle |
Approved 14-11. See Breakdown |
| Week 14 | ||
| Galatians | Michigan Maulers 2 | Decision |
|
OF
Jerry Hairston Jr.
Cin SP Aaron Harang Cin SP Jeremy Guthrie Bal |
DH
Gary Sheffield
NYN 2B Clint Barmes Col SP Glen Perkins Min |
Approved 20-0. See Breakdown |