| Week | Add | Drop |
| Pre-Season |
Round 1: 3B Miguel Vargas - ChA Round 2: SS Geraldo Perdomo - Ari Round A: SP Roki Sasaki - LAD | |
| Week 1 |
Round 1: OF Lars Nootbaar - StL Round 2: 1B Matt Mervis - Mia Round 3: OF Victor Scott - StL |
Round 3: OF Joey Loperfido - Tor |
| Week 2 |
Round 1: SP Chase Dollander - Col Round 2: SP Matthew Liberatore - StL |
Round 1: SP Nick Martinez - Cin Round 2: 1B Matt Mervis - Mia |
| Week 3 |
Round 1: 3B Noelvi Marte - Cin |
Round 1: OF Alec Burleson - StL |
| Week 4 |
Round 1: OF Tim Tawa - Ari Round 2: 3B Alex Freeland - LAD Round 3: OF Colby Thomas - Oak |
Round 2: OF Nolan Jones - Cle Round 3: SP Justin Verlander - SF |
| Week 5 |
Round 1: 3B Caleb Durbin - Mil Round 2: OF Emmanuel Rodriguez - Min |
Round 1: 3B Miguel Vargas - ChA Round 2: 3B Joey Ortiz - Mil |
| Week 6 |
Round 1: SP Eury Perez - Mia |
Round 1: OF Michael Conforto - LAD |
| 1st Team | 2nd Team |
| Pre-Season | |
| Rocket City Trash Pandas | Yankoneout |
|
OF
Pete Crow-Armstrong
ChN |
Round 9, 8th Pick (SP Taj Bradley TB) |
| Pre-Season | |
| Rocket City Trash Pandas | Pawtucket Red Sox |
|
Round 2, 1st Pick (SS Sebastian Walcott Tex) Round 4, 1st Pick (3B Alec Bohm Phi) |
SP
Cole Ragans
KC SP George Kirby Sea |
| Pre-Season | |
| Rocket City Trash Pandas | Yankoneout |
|
3B
Jordan Westburg
Bal |
2B
Matt McLain
Cin |
| Pre-Season | |
| Rocket City Trash Pandas | Al Davis Rastafarians |
|
Round 3, 1st Pick (SP Ronel Blanco Hou) |
1B
Christian Walker
Hou |
| Pre-Season | |
| Rocket City Trash Pandas | Yankoneout |
|
C
J.T. Realmuto
Phi 2B Jazz Chisholm Jr. NYA |
3B
Royce Lewis
Min Round 3, 8th Pick (1B Nick Kurtz Oak) |
| Pre-Season | |
| Rocket City Trash Pandas | Pawtucket Red Sox |
|
Round 3, 8th Pick (1B Nick Kurtz Oak) Round 1, 1st Pick (SP Max Fried NYA) |
SP
Chris Sale
Atl 3B Manny Machado SD |
| Pre-Season | |
| Rocket City Trash Pandas | Boognish Rising |
|
Round 5, 1st Pick (1B Kyle Manzardo Cle) |
1B
Christian Encarnacion-Strand
Cin |
| Pre-Season | |
| Rocket City Trash Pandas | Hillsboro Hops |
|
3B
Manny Machado
SD 3B Matt Shaw ChN |
OF
Luis Robert Jr.
ChA OF Spencer Steer Cin |
| Week 6 | |
| Rocket City Trash Pandas | The Shogun of Harlem |
|
SP
Chris Sale
Atl |
1B
Jonathan Aranda
TB |