| Week | Add | Drop |
| Pre-Season |
Round A: 2B Luisangel Acuna - NYN Round C: SP Bubba Chandler - Pit |
Round A: C Connor Wong - Bos Round C: RP Hector Neris - Atl |
| Week 3 |
Round 2: 1B Ty France - Min |
| 1st Team | 2nd Team |
| Pre-Season | |
| Monroe Monarchs | Al Davis Rastafarians |
|
OF
Ronald Acuna Jr.
Atl 3B Mark Vientos NYN OF Jasson Dominguez NYA |
SP
Max Fried
NYA 3B Rafael Devers Bos OF Jackson Chourio Mil Round 5, 5th Pick (SS Xavier Edwards Mia) Round 1, 9th Pick (OF Jurickson Profar Atl) |
| Pre-Season | |
| Monroe Monarchs | Boognish Rising |
|
SP
Grayson Rodriguez
Bal C Francisco Álvarez NYN |
Round 2, 3rd Pick (SP Michael King SD) |
| Pre-Season | |
| Monroe Monarchs | Pawtucket Red Sox |
|
1B
Vladimir Guerrero Jr.
Tor Round 4, 2nd Pick (SP Justin Steele ChN) Round 14, 2nd Pick (SP Dustin May LAD) |
1B
Pete Alonso
NYN SP Michael King SD SS Anthony Volpe NYA SP Shota Imanaga ChN Round 14, 10th Pick (SP Sean Manaea NYN) Round 15, 10th Pick (SP Clarke Schmidt NYA) Round 16, 10th Pick (OF Ceddanne Rafaela Bos) |
| Pre-Season | |
| Monroe Monarchs | Al Davis Rastafarians |
|
SP
Walker Buehler
Bos C Cal Raleigh Sea 2B Bryson Stott Phi OF Bryan De La Cruz Atl OF Evan Carter Tex |
SP
Zach Eflin
Bal OF Teoscar Hernández LAD RP Jhoan Duran Min C Shea Langeliers Oak SS Jeremy Pena Hou |
| Pre-Season | |
| Monroe Monarchs | Pawtucket Red Sox |
|
OF
Jackson Chourio
Mil Round 2, 3rd Pick (SP Michael King SD) |
SP
Framber Valdez
Hou OF Jarren Duran Bos |
| Pre-Season | |
| Monroe Monarchs | Al Davis Rastafarians |
|
SP
Zach Eflin
Bal RP Pete Fairbanks TB SS Colson Montgomery ChA SS Max Muncy Oak |
SP
Reynaldo Lopez
Atl SP Seth Lugo KC OF Christopher Morel TB 2B Brooks Lee Min |
| Pre-Season | |
| Monroe Monarchs | Yankoneout |
|
RP
Jordan Romano
Phi Round 9, 2nd Pick (1B Ryan Mountcastle Bal) |
OF
Byron Buxton
Min 2B Brandon Lowe TB |
| Pre-Season | |
| Monroe Monarchs | The Shogun of Harlem |
|
Round 6, 2nd Pick (SP Gavin Williams Cle) |
SP
Tyler Glasnow
LAD |
| Week 1 | |
| Monroe Monarchs | Al Davis Rastafarians |
|
OF
Jurickson Profar
Atl |
C
J.T. Realmuto
Phi |
| Week 1 | |
| Monroe Monarchs | Pawtucket Red Sox |
|
C
J.T. Realmuto
Phi |
1B
Bryce Eldridge
SF |
| Week 6 | |
| Monroe Monarchs | Al Davis Rastafarians |
|
2B
Luisangel Acuna
NYN SS Jordan Lawlar Ari 1B Bryce Eldridge SF OF Walker Jenkins Min |
SP
Sonny Gray
StL 2B Zach McKinstry Det 2B Brendan Donovan StL C Yainer Diaz Hou |