| Week | Add | Drop |
| Pre-Season |
Round 1: OF Joshua Baez  Round 2: SS Sebastian Walcott  Round A: SP Kade Anderson  |
Round A: RP Jose Ferrer |
| Week 1 |
Round 1: OF Jordan Walker Round 2: 1B Rhys Hoskins  Round 3: OF Eduardo Quintero  | |
| Week 2 |
Round 1: SP Taj Bradley  |
Round 1: 1B Rhys Hoskins |
| Week 3 |
Round 1: SP Kade Anderson |
Round 1: 3B Josh Jung |
| Week 4 |
Round 1: RP Joel Kuhnel  |
Round 1: OF Eduardo Quintero |
| Week 5 |
Round 2: OF Dylan Crews  |
Round 2: RP Joel Kuhnel |
| Week 6 |
Round 1: SP Elmer Rodriguez  Round 3: SP Didier Fuentes  |
Round 1: SP Jeffrey Springs Round 3: SP Elmer Rodriguez |
| 1st Team | 2nd Team |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
|
RP
Edwin Diaz
|
SS
Sebastian Walcott
Round 3, 2nd Pick (SP Kevin Gausman  ) |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
1B
Rafael Devers
 SS CJ Abrams SP Hunter Brown  |
SS
Mookie Betts
OF James Wood Round 5, 2nd Pick (SP Cam Schlittler ) |
| Pre-Season | |
| Pawtucket Red Sox | Boognish Rising |
3B
Bo Bichette
 SP Logan Webb OF Jackson Chourio  |
OF
Mike Trout
 SP Jacob deGrom 3B Junior Caminero  SP Andrew Painter  |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
OF
Mike Trout
SS Mookie Betts OF James Wood |
SS
Bobby Witt Jr.
 |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
SP
Jacob deGrom
|
Round 4, 4th Pick (RP Aroldis Chapman  ) |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
|
SP
Max Fried
Round 19, 12th Pick |
Round 1, 8th Pick (SP Kyle Bradish  ) |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
1B
Yandy Diaz
|
Round 6, 4th Pick (C Ivan Herrera ) |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
|
Round 15, 12th Pick (OF Adolis Garcia ) Round 16, 12th Pick (SP Jack Flaherty  )Round 17, 12th Pick (RP Robert Suarez )Round 18, 12th Pick (SP Justin Verlander ) |
Round 11, 8th Pick (SP Gerrit Cole ) |
| Pre-Season | |
| Pawtucket Red Sox | Churchills |
|
RP
Trevor Megill
|
Round 6, 6th Pick (OF Walker Jenkins ) |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
2B
Ketel Marte
 SP Yoshinobu Yamamoto Round 13, 12th Pick (SP Luis Gil )Round 14, 12th Pick (SP Luis Severino ) |
SP
Garrett Crochet
Round 1, 9th Pick (C Drake Baldwin )Round 1, 2nd Pick (SS Leo De Vries )Round 6, 2nd Pick (RP Daniel Palencia  ) |
| Week 1 | |
| Pawtucket Red Sox | Monroe Monarchs |
|
OF
Kyle Schwarber
SP Joe Ryan |
2B
Jazz Chisholm Jr.
OF Jackson Chourio |
| Week 4 | |
| Pawtucket Red Sox | Monroe Monarchs |
|
RP
Aroldis Chapman
SP Garrett Crochet 1B Kyle Manzardo |
OF
Ryan O'Hearn
 SP Jeffrey Springs SP Yoshinobu Yamamoto |