| Week | Add | Drop |
| Pre-Season |
Round 1: SP Trevor Williams - Was Round 2: SS Max Muncy - Oak Round A: SS Sebastian Walcott - Tex | |
| Week 1 |
Round 3: 2B Wilmer Flores - SF | |
| Week 2 |
Round 1: OF Harrison Bader - Min |
Round 1: RP David Bednar - Pit Round 2: SS Max Muncy - Oak |
| Week 3 |
Round 1: RP Jason Adam - SD Round 2: SP Jose Quintana - Mil Round 3: OF Alex Call - Was |
Round 1: OF Harrison Bader - Min |
| Week 4 |
Round 1: C Dalton Rushing - LAD |
Round 1: SP Trevor Williams - Was Round 2: OF Alex Call - Was |
| Week 5 |
Round 1: 1B Luis Arraez - SD Round 2: SP Clayton Kershaw - LAD |
Round 1: RP Jason Adam - SD Round 2: 1B Colt Keith - Det |
| Week 6 |
Round 1: SP Hunter Dobbins - Bos Round 3: OF Alex Call - Was |
Round 3: SP Hunter Dobbins - Bos |
| Week 7 |
Round 3: 1B Triston Casas - Bos |
Round 3: OF Alex Call - Was |
| Week 8 |
Round 1: 2B Hyeseong Kim - LAD | |
| Week 9 |
Round 3: C Jose Trevino - Cin |
Round 2: 2B Tyler Fitzgerald - SF |
| Week 10 |
Round 2: OF Charlie Condon - Col |
Round 2: C Jose Trevino - Cin |
| Week 12 |
Round 1: 2B Jeff McNeil - NYN Round 2: SP Pablo Lopez - Min |
Round 1: 1B Nathaniel Lowe - Was Round 2: 2B Jeff McNeil - NYN |
| 1st Team | 2nd Team |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
|
1B
Pete Alonso
NYN SP Michael King SD SS Anthony Volpe NYA SP Shota Imanaga ChN Round 14, 10th Pick (SP Sean Manaea NYN) Round 15, 10th Pick (SP Clarke Schmidt NYA) Round 16, 10th Pick (OF Ceddanne Rafaela Bos) |
1B
Vladimir Guerrero Jr.
Tor Round 4, 2nd Pick (SP Justin Steele ChN) Round 14, 2nd Pick (SP Dustin May LAD) |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
|
SP
Framber Valdez
Hou OF Jarren Duran Bos |
OF
Jackson Chourio
Mil Round 2, 3rd Pick (SP Michael King SD) |
| Pre-Season | |
| Pawtucket Red Sox | Rocket City Trash Pandas |
|
SP
Cole Ragans
KC SP George Kirby Sea |
Round 2, 1st Pick (SS Sebastian Walcott Tex) Round 4, 1st Pick (3B Alec Bohm Phi) |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
SP
Hunter Greene
Cin SP Logan Gilbert Sea |
Round 2, 5th Pick (SP Spencer Schwellenbach Atl) Round 4, 5th Pick (SP Jack Flaherty Det) |
| Pre-Season | |
| Pawtucket Red Sox | Yankoneout |
|
1B
Paul Goldschmidt
NYA |
SP
Max Fried
NYA |
| Pre-Season | |
| Pawtucket Red Sox | Hillsboro Hops |
|
SP
Zac Gallen
Ari |
Round 4, 4th Pick (SP Shane Baz TB) |
| Pre-Season | |
| Pawtucket Red Sox | Boognish Rising |
|
SS
Ezequiel Tovar
Col |
Round 4, 3rd Pick (SS Masyn Winn StL) |
| Pre-Season | |
| Pawtucket Red Sox | Yankoneout |
|
Round 5, 10th Pick (SP Nick Lodolo Cin) Round 6, 10th Pick (SP Walker Buehler Bos) |
SP
Chris Sale
Atl SP Garrett Crochet Bos |
| Pre-Season | |
| Pawtucket Red Sox | Al Davis Rastafarians |
|
SP
Max Fried
NYA |
OF
Michael Harris II
Atl |
| Pre-Season | |
| Pawtucket Red Sox | Boognish Rising |
|
SP
Cristopher Sanchez
Phi |
SS
Anthony Volpe
NYA |
| Pre-Season | |
| Pawtucket Red Sox | Rocket City Trash Pandas |
|
SP
Chris Sale
Atl 3B Manny Machado SD |
Round 3, 8th Pick (1B Nick Kurtz Oak) Round 1, 1st Pick (SP Max Fried NYA) |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
SP
Garrett Crochet
Bos |
Round 5, 5th Pick (SS Xavier Edwards Mia) |
| Pre-Season | |
| Pawtucket Red Sox | Hillsboro Hops |
|
OF
Michael Harris II
Atl |
Round 2, 4th Pick (SP Hunter Brown Hou) |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
Round 17, 10th Pick (SP Chris Paddack Min) Round 18, 10th Pick (SP Caden Dana LAA) Round 19, 10th Pick (SP Will Warren NYA) |
Round 12, 5th Pick (SP Bubba Chandler Pit) |
| Pre-Season | |
| Pawtucket Red Sox | Al Davis Rastafarians |
|
Round 5, 5th Pick (SS Xavier Edwards Mia) |
SP
Shota Imanaga
ChN |
| Week 1 | |
| Pawtucket Red Sox | Monroe Monarchs |
|
1B
Bryce Eldridge
SF |
C
J.T. Realmuto
Phi |
| Week 5 | |
| Pawtucket Red Sox | Al Davis Rastafarians |
|
SP
Justin Steele
ChN 1B Luis Arraez SD RP Trevor Megill Mil SS Gunnar Henderson Bal 1B Nick Kurtz Oak |
SP
Nathan Eovaldi
Tex 2B Ketel Marte Ari RP Edwin Diaz NYN OF Jasson Dominguez NYA SS CJ Abrams Was |
| Week 7 | |
| Pawtucket Red Sox | Al Davis Rastafarians |
|
SP
Bubba Chandler
Pit C Dalton Rushing LAD |
1B
Nathaniel Lowe
Was RP Jhoan Duran Min |
| Week 9 | |
| Pawtucket Red Sox | Monroe Monarchs |
|
SS
Mookie Betts
LAD 3B Austin Riley Atl OF Jasson Dominguez NYA 2B Hyeseong Kim LAD |
3B
Rafael Devers
Bos OF Julio Rodriguez Sea SS Anthony Volpe NYA C Ivan Herrera StL |
| Week 9 | |
| Pawtucket Red Sox | Al Davis Rastafarians |
|
SP
Clayton Kershaw
LAD SP Shane Baz TB SS Sebastian Walcott Tex |
SP
Andrew Heaney
Pit 3B Isaac Paredes Hou SP Reese Olson Det |
| Week 10 | |
| Pawtucket Red Sox | Al Davis Rastafarians |
|
OF
Charlie Condon
Col |
RP
Trevor Megill
Mil |
| Week 11 | |
| Pawtucket Red Sox | Hillsboro Hops |
|
SP
Logan Webb
SF |
|
| Week 13 | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
1B
Triston Casas
Bos |
1B
Yandy Diaz
TB |
| Week 13 | |
| Pawtucket Red Sox | Hillsboro Hops |
|
SS
Anthony Volpe
NYA |
SS
Bo Bichette
Tor |