| Week | Add | Drop |
| 1st Team | 2nd Team |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
RP
Edwin Diaz
 |
SS
Sebastian Walcott
 Round 3, 2nd Pick |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
1B
Rafael Devers
 SS CJ Abrams  SP Hunter Brown  |
SS
Mookie Betts
OF James Wood Round 5, 2nd Pick |
| Pre-Season | |
| Pawtucket Red Sox | Boognish Rising |
3B
Bo Bichette
 SP Logan Webb OF Jackson Chourio  |
OF
Mike Trout
 SP Jacob deGrom 3B Junior Caminero  SP Andrew Painter  |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
OF
Mike Trout
SS Mookie Betts OF James Wood |
SS
Bobby Witt Jr.
 |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
SP
Jacob deGrom
|
Round 4, 4th Pick |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
SP
Max Fried
 Round 19, 12th Pick |
Round 1, 8th Pick |
| Pre-Season | |
| Pawtucket Red Sox | Fredericksburg Nationals |
|
1B
Yandy Diaz
|
Round 6, 4th Pick |
| Pre-Season | |
| Pawtucket Red Sox | Monroe Monarchs |
|
Round 15, 12th Pick Round 16, 12th Pick Round 17, 12th Pick Round 18, 12th Pick |
Round 11, 8th Pick |
| Pre-Season | |
| Pawtucket Red Sox | Churchills |
|
RP
Trevor Megill
|
Round 6, 6th Pick |