| Week | Add | Drop |
| Pre-Season |
Round 1: OF Michael Conforto - SF Round 2: C Alejandro Kirk - Tor Round A: 3B Coby Mayo - Bal Round B: C Ethan Salas - SD |
Round A: C Elias Diaz - SD Round B: C Freddy Fermin - KC |
| Week 1 |
Round 2: SP Tanner Houck - Bos | |
| Week 2 |
Round 1: SS Tyler Freeman - Cle Round 2: OF Heston Kjerstad - Bal | |
| Week 3 |
Round 1: 3B Anthony Rendon - LAA Round 2: SP Bailey Ober - Min |
Round 2: RP Jose Leclerc - Tex |
| Week 4 |
Round 1: RP Kirby Yates - Tex |
Round 1: RP Yuki Matsui - SD |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos |
Round 1: 3B Anthony Rendon - LAA |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: 3B Bryan Ramos - ChA |
Round 1: SP Yariel Rodriguez - Tor Round 2: OF Parker Meadows - Det |
| Week 7 |
Round 1: SP Taj Bradley - TB Round 2: 3B Brady House - Was |
Round 1: SP Logan Allen - Cle Round 2: SS Tyler Freeman - Cle |
| Week 8 |
Round 1: 2B Miguel Vargas - ChA Round 2: C Tyler Soderstrom - Oak |
Round 1: C Alejandro Kirk - Tor Round 2: 3B Bryan Ramos - ChA |
| Week 10 |
Round 1: OF Lane Thomas - Cle |
Round 1: 3B Tyler Black - Mil |
| Week 11 |
Round 1: 2B Connor Norby - Mia Round 2: SS Adael Amador - Col |
Round 1: 2B Edouard Julien - Min Round 2: OF Ceddanne Rafaela - Bos |
| Week 12 |
Round 1: SP Drew Thorpe - ChA Round 2: 2B Enmanuel Valdez - Bos |
Round 1: OF Will Benson - Cin Round 2: SP Max Meyer - Mia |
| Week 13 |
Round 1: 1B Ben Rice - NYA Round 2: 2B Brett Wisely - SF |
Round 1: SP Hurston Waldrep - Atl |
| Week 14 |
Round 1: 1B Jhonkensy Noel - Cle Round 2: SP Brandon Pfaadt - Ari |
Round 1: OF Michael Conforto - SF |
| Week 15 |
Round 1: 3B Brett Harris - Oak Round 2: 1B Moises Ballesteros - ChN |
Round 1: 2B Enmanuel Valdez - Bos Round 2: SS Adael Amador - Col |
| Week 16 |
Round 1: OF Rece Hinds - Cin Round 2: C Kyle Higashioka - SD |
Round 1: 3B Eugenio Suarez - Ari Round 2: OF Lazaro Montes - Sea |
| Week 18 |
Round 1: C Adrian Del Castillo - Ari Round 2: RP Ben Joyce - LAA | |
| Week 19 |
Round 1: SS JJ Wetherholt - StL Round 2: SP Jose Quintana - NYN |
Round 1: C Tyler Soderstrom - Oak Round 2: 3B Brett Harris - Oak |
| Week 20 |
Round 1: SS Matt Shaw - ChN |
Round 1: RP José Alvarado - Phi |
| Week 22 |
Round 2: 1B Jac Caglianone - KC |
Round 2: C Kyle Higashioka - SD |
| 1st Team | 2nd Team |
| Pre-Season | |
| Arkansas Travelers | Diamond Dust |
|
2B
Gleyber Torres
NYA |
|
| Pre-Season | |
| Arkansas Travelers | This One's for Trader Joe!!! |
|
OF
Mike Trout
LAA |
|
| Week 3 | |
| Arkansas Travelers | Whiz Kids |
|
1B
Anthony Rizzo
NYA C Elias Diaz Col 3B Alex Bregman Hou SP Tanner Houck Bos SP Cristian Javier Hou |
3B
Josh Jung
Tex SP Max Meyer Mia OF Ceddanne Rafaela Bos 1B Christian Encarnacion-Strand Cin SP Yariel Rodriguez Tor |
| Week 10 | |
| Arkansas Travelers | Santa’s Nation |
|
SP
Luis Castillo
Sea |
OF
Jordan Walker
StL |
| Week 12 | |
| Arkansas Travelers | Whiz Kids |
|
SP
Luis Severino
NYN OF Lane Thomas Was |
OF
Lazaro Montes
Sea SP Hurston Waldrep Atl OF Joey Loperfido Hou |
| Week 13 | |
| Arkansas Travelers | Santa’s Nation |
|
OF
Randy Arozarena
TB |
Round 2, 10th Pick (SP Luis Castillo Sea) |
| Week 14 | |
| Arkansas Travelers | Twins Rock |
|
SP
Gavin Stone
LAD |
Round 3, 7th Pick (SP Bryan Woo Sea) |
| Week 17 | |
| Arkansas Travelers | Twins Rock |
|
OF
Rece Hinds
Cin SP Bryce Miller Sea Round 4, 1st Pick (OF Brandon Nimmo NYN) Round 19, 1st Pick (3B Ernie Clement Tor) |
Round 2, 7th Pick (RP Raisel Iglesias Atl) Round 4, 7th Pick (SP Bailey Ober Min) |