| Week | Add | Drop |
| Pre-Season |
Round 1: RP Yimi Garcia - Tor |
Round 1: SP Jose Quintana - NYN |
| Week 1 |
Round 1: RP Jason Foley - Det Round 2: 3B Trey Lipscomb - Was | |
| Week 2 |
Round 1: RP Paul Sewald - Ari Round 2: RP Kevin Ginkel - Ari |
Round 2: SP Eury Perez - Mia |
| Week 3 |
Round 1: SP Yariel Rodriguez - Tor Round 2: SS Kevin Newman - Ari |
Round 1: RP Yimi Garcia - Tor Round 2: OF Parker Meadows - Det |
| Week 4 |
Round 1: OF Jonatan Clase - Sea Round 2: OF Bryan De La Cruz - Mia |
Round 1: 3B Trey Lipscomb - Was Round 2: SP Ricky Tiedemann - Tor |
| Week 5 |
Round 1: RP James McArthur - KC Round 2: 2B Josh Rojas - Sea |
Round 1: SP Yariel Rodriguez - Tor Round 2: OF Jonatan Clase - Sea |
| Week 6 |
Round 1: RP Garrett Whitlock - Bos Round 2: C Tyler Stephenson - Cin |
Round 1: RP Kevin Ginkel - Ari Round 2: C Alejandro Kirk - Tor |
| Week 7 |
Round 1: SP Simeon Woods Richardson - Min Round 2: SP Garrett Crochet - ChA |
Round 2: 2B Colt Keith - Det Round 2: SS Kevin Newman - Ari |
| 1st Team | 2nd Team |
| Pre-Season | |
| Buffalo Horseheads | Vanilla Gorillas |
|
SP
Nathan Eovaldi
Tex DH Shohei Ohtani LAD 3B Alec Bohm Phi |
3B
Josh Jung
Tex OF Jordan Walker StL SP Eury Perez Mia |
| Pre-Season | |
| Buffalo Horseheads | New York City MSG |
|
C
Danny Jansen
Tor |
Round 2, 11th Pick (2B Colt Keith Det) Round 3, 11th Pick (SP Carlos Rodon NYA) |
| Pre-Season | |
| Buffalo Horseheads | Vanilla Gorillas |
|
Round 3, 8th Pick (SP Chris Bassitt Tor) |
SS
C.J. Abrams
Was |
| Pre-Season | |
| Buffalo Horseheads | Fightin Phils |
|
Round 6, 8th Pick (DH J.D. Martinez NYN) |
Round 17, 5th Pick (SP Reese Olson Det) |
| Week 3 | |
| Buffalo Horseheads | Bat Crack Fever |
|
SS
Anthony Volpe
NYA |
OF
Seiya Suzuki
ChN |