| Week | Add | Drop |
| Pre-Season |
Round 1: OF Will Benson - Cin Round 2: C Gary Sanchez - Mil Round A: C Bo Naylor - Cle Round B: SP Luis Severino - NYN |
Round A: C Travis d'Arnaud - Atl Round B: 1B Brandon Belt - F/A |
| Week 1 |
Round 2: 3B Jared Triolo - Pit | |
| Week 2 |
Round 1: SP Tyler Wells - Bal Round 2: OF Micahel Taylor - Pit | |
| Week 3 |
Round 1: SP Matt Manning - Det Round 2: SS Gavin Lux - LAD | |
| Week 4 |
Round 1: RP Kirby Yates - Tex | |
| Week 5 |
Round 1: 3B Orelvis Martinez - Tor Round 2: OF Jo Adell - LAA |
Round 1: SP Matt Manning - Det Round 2: RP Yuki Matsui - SD |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: 3B Patrick Wisdom - ChN |
Round 1: 3B Mark Vientos - NYN Round 2: SP Yariel Rodriguez - Tor |
| 1st Team | 2nd Team |
| Pre-Season | |
| Altoona Curve | Red Dragon |
|
Round 7, 11th Pick (RP Kenley Jansen Bos) |
SP
Chris Sale
Atl |
| Pre-Season | |
| Altoona Curve | Red Dragon |
|
Round 6, 7th Pick (OF Giancarlo Stanton NYA) |
SP
Justin Verlander
Hou |
| Pre-Season | |
| Altoona Curve | Red Dragon |
|
C
Bo Naylor
Cle |
Round 10, 12th Pick (OF Ceddanne Rafaela Bos) |
| Pre-Season | |
| Altoona Curve | Basket Case |
|
2B
Marcus Semien
Tex Round 8, 11th Pick (DH J.D. Martinez NYN) |
SP
Tyler Glasnow
LAD 1B Andrew Vaughn ChA 2B Colt Keith Det Round 1, 8th Pick (SS Carlos Correa Min) |
| Pre-Season | |
| Altoona Curve | Dave's Destroyers |
|
Round 9, 11th Pick (DH Justin Turner Tor) |
OF
James Wood
Was |
| Pre-Season | |
| Altoona Curve | First Degree Burnes |
|
Round 1, 11th Pick (2B Nico Hoerner ChN) Round 6, 11th Pick (2B Luis Arraez Mia) |
SP
Patrick Sandoval
LAA |
| Pre-Season | |
| Altoona Curve | Mesa Solar Sox |
|
Round 2, 11th Pick (SP Justin Verlander Hou) |
C
Freddy Fermin
KC |
| Pre-Season | |
| Altoona Curve | Dave's Destroyers |
|
Round 3, 11th Pick (C Francisco Álvarez NYN) |
SP
Clarke Schmidt
NYA |
| Pre-Season | |
| Altoona Curve | Al Davis Kingpins |
|
SS
Willy Adames
Mil |
1B
Yandy Diaz
TB |
| Pre-Season | |
| Altoona Curve | First Degree Burnes |
|
SP
Kevin Gausman
Tor OF Bryan Reynolds Pit C Will Smith LAD |
SS
Junior Caminero
TB Round 1, 7th Pick (OF Dylan Crews Was) Round 6, 7th Pick (OF Giancarlo Stanton NYA) |
| Week 2 | |
| Altoona Curve | Red Dragon |
|
SP
Logan Allen
Cle |
OF
Nick Castellanos
Phi |
| Week 4 | |
| Altoona Curve | Red Dragon |
|
RP
Evan Phillips
LAD |
RP
Kenley Jansen
Bos OF Chase DeLauter Cle |
| Week 4 | |
| Altoona Curve | Chaos Creators |
|
SP
Aaron Nola
Phi SP Logan Webb SF |
1B
Nate Lowe
Tex OF Evan Carter Tex |
| Week 5 | |
| Altoona Curve | Basket Case |
|
OF
Nick Castellanos
Phi RP Kirby Yates Tex |
RP
Carlos Estevez
LAA SP Max Meyer Mia SP Garrett Crochet ChA SP Yariel Rodriguez Tor |
| Week 5 | |
| Altoona Curve | Red Dragon |
|
1B
Nate Lowe
Tex |
SP
Triston McKenzie
Cle |