| Week | Add | Drop |
| Week 1 |
Round 1: RP Daniel Hudson - LAD Round 2: SP Cody Bradford - Tex | |
| Week 2 |
Round 1: RP Ronel Blanco - Hou Round 2: 3B Oliver Dunn - Mil | |
| Week 3 |
Round 1: SP Martin Perez - SD Round 2: SP Joe Ross - Mil |
Round 1: RP Daniel Hudson - LAD Round 2: OF Tommy Edman - LAD |
| Week 4 |
Round 1: RP James McArthur - KC Round 2: OF Jesse Winker - NYN |
Round 1: 3B Oliver Dunn - Mil Round 2: SP Joe Boyle - Oak |
| Week 5 |
Round 1: SS Amed Rosario - LAD |
Round 1: SP Joe Ross - Mil |
| Week 6 |
Round 1: 1B Tyler Nevin - Oak Round 2: 2B Willi Castro - Min |
Round 1: 2B Thairo Estrada - SF Round 2: OF Sal Frelick - Mil |
| Week 7 |
Round 1: SP Hayden Wesneski - ChN Round 2: SP Alec Marsh - KC |
Round 1: SP Martin Perez - SD Round 2: 1B Tyler Nevin - Oak |
| Week 8 |
Round 1: SS Kevin Newman - Ari Round 2: RP José Soriano - LAA |
Round 1: SP Hayden Wesneski - ChN Round 2: SP Braxton Garrett - Mia |
| Week 9 |
Round 1: OF Alec Burleson - StL Round 1: OF Alec Burleson - StL Round 2: SP JP Sears - Oak |
Round 1: SS Kevin Newman - Ari Round 1: SS Kevin Newman - Ari Round 2: 2B Xander Bogaerts - SD |
| Week 10 |
Round 1: SP Ryan Weathers - Mia |
Round 1: SP Bryce Elder - Atl Round 2: SS Amed Rosario - Cin |
| Week 11 |
Round 1: OF TJ Friedl - Cin Round 2: SS Edmundo Sosa - Phi |
Round 2: SP Jackson Jobe - Det |
| Week 12 |
Round 1: SS David Hamilton - Bos Round 2: SP Brandon Pfaadt - Ari |
Round 1: OF Alec Burleson - StL Round 2: SS Edmundo Sosa - Phi |
| Week 13 |
Round 1: 1B Nolan Schanuel - LAA Round 2: SP Jonathan Cannon - ChA |
Round 1: SP Ryan Weathers - Mia Round 2: C Keibert Ruiz - Was |
| Week 14 |
Round 1: SP David Festa - Min |
Round 1: SP JP Sears - Oak |
| Week 15 |
Round 2: OF Parker Meadows - Det |
Round 2: OF Blake Perkins - Mil |
| Week 16 |
Round 1: SP River Ryan - LAD |
Round 1: RP José Soriano - LAA |
| Week 22 |
Round 2: SP Alec Marsh - KC |
| 1st Team | 2nd Team |
| Pre-Season | |
| Wilmington Potomacs | Altoona Curve |
|
SP
Patrick Sandoval
LAA |
|
| Pre-Season | |
| Wilmington Potomacs | Basket Case |
|
OF
Jose Siri
TB |
|
| Pre-Season | |
| Wilmington Potomacs | The Halle-Day Saints |
|
3B
Brian Anderson
Atl |
|
| Pre-Season | |
| Wilmington Potomacs | Red Dragon |
|
RP
Jordan Romano
Tor |
|
| Pre-Season | |
| Wilmington Potomacs | Basket Case |
|
3B
Royce Lewis
Min |
|
| Pre-Season | |
| Wilmington Potomacs | Corpus Christi Hooks |
|
OF
Wyatt Langford
Tex |
OF
Kyle Schwarber
Phi |
| Pre-Season | |
| Wilmington Potomacs | Roger Clemens |
|
SS
Jordan Lawlar
Ari |
SP
Kodai Senga
NYN |
| Pre-Season | |
| Wilmington Potomacs | Altoona Curve |
|
SS
Junior Caminero
TB |
SP
Kevin Gausman
Tor OF Bryan Reynolds Pit C Will Smith LAD |
| Week 5 | |
| Wilmington Potomacs | Corpus Christi Hooks |
|
OF
Kyle Schwarber
Phi |
3B
Isaac Paredes
TB SP José Butto NYN SP Yoshinobu Yamamoto LAD |
| Week 8 | |
| Wilmington Potomacs | The Halle-Day Saints |
|
C
Will Smith
LAD |
2B
Bryson Stott
Phi C Logan O'Hoppe LAA |
| Week 10 | |
| Wilmington Potomacs | Altoona Curve |
|
SS
Jordan Lawlar
Ari 1B Kyle Manzardo Cle |
SS
Carlos Correa
Min SP Reese Olson Det |
| Week 11 | |
| Wilmington Potomacs | Red Dragon |
|
SP
Kevin Gausman
Tor SS Dansby Swanson ChN OF Steven Kwan Cle |
RP
Clay Holmes
NYA SS Jeremy Pena Hou OF JJ Bleday Oak |
| Week 13 | |
| Wilmington Potomacs | Red Dragon |
|
OF
JJ Bleday
Oak C Logan O'Hoppe LAA SP Reese Olson Det |
SP
Kevin Gausman
Tor C Danny Jansen Tor OF Blake Perkins Mil |