| Week | Add | Drop |
| Pre-Season |
Round 1: SP Kumar Rocker - Tex Round 2: RP Luke Jackson - Tex Round 3: SS J.P. Crawford - Sea Round A: SP Jesus Luzardo - Phi |
Round 3: RP Chris Martin - Tex Round A: SP Zebby Matthews - Min |
| Week 1 |
Round 1: OF Giancarlo Stanton - NYA Round 2: SP Grant Holmes - Atl Round 3: OF Gavin Sheets - SD |
Round 3: SP Grant Holmes - Atl |
| Week 2 |
Round 2: 1B Andrew Vaughn - ChA |
Round 2: OF Gavin Sheets - SD |
| Week 3 |
Round 1: OF Mike Yastrzemski - SF Round 2: 1B Jeimer Candelario - Cin Round 3: SP Hayden Wesneski - Hou |
Round 2: SS J.P. Crawford - Sea Round 3: OF Giancarlo Stanton - NYA |
| Week 4 |
Round 1: 1B Willson Contreras - StL Round 2: OF Heston Kjerstad - Bal Round 3: SS Isiah Kiner-Falefa - Pit |
Round 1: 1B Jeimer Candelario - Cin Round 2: SP Kumar Rocker - Tex Round 3: 1B Andrew Vaughn - ChA |
| Week 5 |
Round 1: RP Camilo Doval - SF Round 3: SP Ryan Pepiot - TB |
Round 1: OF Heston Kjerstad - Bal Round 3: SS Isiah Kiner-Falefa - Pit |
| Week 6 |
Round 1: 3B Miguel Vargas - ChA Round 2: 3B Ryan McMahon - Col |
Round 1: RP Justin Martinez - Ari Round 2: RP Camilo Doval - SF |
| 1st Team | 2nd Team |