| Week | Add | Drop |
| Pre-Season |
Round A: SP Shota Imanaga - ChN | |
| Week 1 |
Round 2: RP Ronel Blanco - Hou | |
| Week 2 |
Round 1: OF Mark Canha - Det Round 2: SP Paul Blackburn - Oak | |
| Week 4 |
Round 2: 2B Rob Refsnyder - Bos |
Round 2: OF Mark Canha - Det |
| Week 5 |
Round 2: RP Reed Garrett - NYN |
Round 2: SP Kenta Maeda - Det |
| Week 6 |
Round 1: OF Wenceel Perez - Det |
Round 1: RP Reed Garrett - NYN |
| 1st Team | 2nd Team |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
OF
Andrew McCutchen
Pit Round 3, 4th Pick (OF Lane Thomas Was) |
SP
Eduardo Rodriguez
Ari RP Camilo Doval SF |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
3B
Rafael Devers
Bos OF Kyle Tucker Hou 3B Gunnar Henderson Bal |
3B
Alex Bregman
Hou DH Shohei Ohtani LAD C Jonah Heim Tex |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
1B
Triston Casas
Bos SS Jackson Holliday Bal Round 5, 4th Pick (1B Jose Abreu Hou) |
SP
Justin Verlander
Hou 1B Christian Walker Ari SP Luis Castillo Sea |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
Round 4, 4th Pick (SP Joe Ryan Min) Round 7, 4th Pick (1B Anthony Rizzo NYA) |
OF
Christopher Morel
ChN Round 9, 11th Pick (OF Jarred Kelenic Atl) Round 9, 12th Pick (SP Hunter Greene Cin) Round 10, 12th Pick (SP Shota Imanaga ChN) Round 11, 12th Pick (SP Ranger Suarez Phi) Round 12, 12th Pick (OF Jarren Duran Bos) |
| Pre-Season | |
| ChiSox3 | The Shogun of Harlem |
|
OF
Adolis Garcia
Tex Round 6, 4th Pick (2B Jorge Polanco Sea) |
2B
Ketel Marte
Ari OF Jordan Walker StL |
| Pre-Season | |
| ChiSox3 | Montgomery Biscuits |
|
SP
Jonathan Gray
Tex |
Round 1, 11th Pick (RP Raisel Iglesias Atl) Round 3, 11th Pick (SP Kyle Bradish Bal) Round 4, 11th Pick (SP Eduardo Rodriguez Ari) |
| Pre-Season | |
| ChiSox3 | The Plantation |
|
SP
Patrick Sandoval
LAA |
Round 3, 6th Pick (C Yainer Diaz Hou) |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
SP
Eduardo Rodriguez
Ari |
Round 7, 12th Pick (OF Cedric Mullins Bal) |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
2B
Ketel Marte
Ari OF Jordan Walker StL |
SP
Framber Valdez
Hou SS C.J. Abrams Was |
| Pre-Season | |
| ChiSox3 | Akron Black Tyrites |
|
SS
Anthony Volpe
NYA |
2B
Colt Keith
Det |
| Pre-Season | |
| ChiSox3 | Omaha Crawfords |
|
Round 3, 6th Pick (C Yainer Diaz Hou) Round 3, 11th Pick (SP Kyle Bradish Bal) |
OF
Jorge Soler
SF SP Joe Musgrove SD |
| Pre-Season | |
| ChiSox3 | Green Wave |
|
OF
Nolan Jones
Col |
OF
Eloy Jimenez
ChA Round 5, 7th Pick (SP Sonny Gray StL) |
| Week 3 | |
| ChiSox3 | Montgomery Biscuits |
|
1B
Kyle Manzardo
Cle |
C
Shea Langeliers
Oak |
| Week 4 | |
| ChiSox3 | Al Davis Rastafarians |
|
RP
Raisel Iglesias
Atl OF Christopher Morel ChN 2B Colt Keith Det |
OF
Giancarlo Stanton
NYA 2B Ozzie Albies Atl SP Reid Detmers LAA |
| Week 4 | |
| ChiSox3 | Omaha Crawfords |
|
SP
Luis Castillo
Sea OF Jarren Duran Bos |
SP
Cole Ragans
KC SS Ezequiel Tovar Col |
| Week 4 | |
| ChiSox3 | Omaha Crawfords |
|
OF
Cedric Mullins
Bal SP Ranger Suarez Phi SS C.J. Abrams Was |
SS
Carlos Correa
Min RP Andres Munoz Sea OF Jordan Walker StL |
| Week 5 | |
| ChiSox3 | Al Davis Rastafarians |
|
1B
Christian Walker
Ari SP Joe Musgrove SD |
1B
Triston Casas
Bos 2B Vaughn Grissom Bos |
| Week 5 | |
| ChiSox3 | Omaha Crawfords |
|
2B
Ozzie Albies
Atl OF Cody Bellinger ChN RP Camilo Doval SF |
3B
Rafael Devers
Bos OF Cedric Mullins Bal SP Joe Ryan Min |
| Week 7 | |
| ChiSox3 | Al Davis Rastafarians |
|
SS
Carlos Correa
Min |
1B
Anthony Rizzo
NYA |
| Week 7 | |
| ChiSox3 | Omaha Crawfords |
|
SP
Hunter Greene
Cin 1B Triston Casas Bos SP Paul Skenes Pit |
SP
Zach Eflin
TB SP Trevor Williams Was OF Jarren Duran Bos SP Bobby Miller LAD |