| Week | Add | Drop |
| Pre-Season |
Round 1: SS Paul DeJong - ChA Round 2: C Alejandro Kirk - Tor Round A: SP John Means - Bal |
Round A: 2B Wilmer Flores - SF |
| Week 1 |
Round 2: SP Emerson Hancock - Sea | |
| Week 2 |
Round 1: 2B Brendan Donovan - StL Round 2: SP Javier Assad - ChN | |
| Week 3 |
Round 1: SP Ranger Suarez - Phi Round 2: SS Jose Caballero - TB |
Round 2: 3B Yoan Moncada - ChA |
| Week 4 |
Round 1: OF Jesse Winker - Was |
Round 1: C Alejandro Kirk - Tor |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: SP John Means - Bal |
Round 1: OF Chas McCormick - Hou Round 2: RP Adbert Alzolay - ChN |
| Week 7 |
Round 1: 1B Jonathan Singleton - Hou Round 2: OF Jonny DeLuca - TB |
Round 1: C Reese McGuire - Bos Round 2: OF Masataka Yoshida - Bos |
| 1st Team | 2nd Team |
| Pre-Season | |
| Biloxi Shuckers | Dave's Destroyers |
|
Round 3, 8th Pick (OF George Springer Tor) |
3B
Noelvi Marte
Cin |
| Pre-Season | |
| Biloxi Shuckers | Bedlam at the Bank |
|
Round 2, 8th Pick (SP Gavin Williams Cle) |
OF
Steven Kwan
Cle |
| Week 5 | |
| Biloxi Shuckers | Bedlam at the Bank |
|
OF
Aaron Hicks
LAA 3B Max Muncy LAD SS Paul DeJong ChA |
SP
Max Meyer
Mia OF Chase DeLauter Cle OF Joey Loperfido Hou |
| Week 7 | |
| Biloxi Shuckers | Bedlam at the Bank |
|
RP
Kenley Jansen
Bos OF Jesse Winker Was C Danny Jansen Tor SP Ranger Suarez Phi SP Justin Steele ChN 2B Brendan Donovan StL |
C
Reese McGuire
Bos SP Ryan Pepiot TB SP Gavin Williams Cle OF Hunter Goodman Col 2B Colt Keith Det SP Taj Bradley TB OF Jordan Beck Col OF Wyatt Langford Tex |