| Week | Add | Drop |
| Pre-Season |
Round 1: SS Brayan Rocchio - Cle Round 2: C Keibert Ruiz - Was Round 3: 2B Willi Castro - Min Round A: SP Eury Perez - Mia Round B: RP Ryan Walker - SF |
Round A: C David Fry - Cle |
| Week 1 |
Round 2: OF Heston Kjerstad - Bal Round 3: 3B Yoan Moncada - LAA |
Round 3: OF Ceddanne Rafaela - Bos |
| Week 2 |
Round 1: C Kyle Teel - ChA Round 2: OF Zac Veen - Col Round 3: SS Edmundo Sosa - Phi |
Round 1: SP Kumar Rocker - Tex Round 2: OF Max Kepler - Phi Round 3: SS Brayan Rocchio - Cle |
| Week 3 |
Round 1: 1B Matt Mervis - Mia Round 2: SS Sebastian Walcott - Tex |
Round 1: 3B Yoan Moncada - LAA Round 2: C Kyle Teel - ChA |
| Week 4 |
Round 1: 2B Luke Keaschall - Min Round 2: 3B Caleb Durbin - Mil |
Round 1: 2B Willi Castro - Min Round 2: 1B Joshua Bell - Was Round 2: 1B Bryce Eldridge - SF |
| Week 5 |
Round 1: OF Jordan Beck - Col Round 2: 1B Bryce Eldridge - SF Round 3: SS Javier Baez - Det |
Round 1: OF Zac Veen - Col Round 2: SS Edmundo Sosa - Phi |
| Week 6 |
Round 1: SP Lucas Giolito - Bos Round 2: SP Gunnar Hoglund - Oak |
Round 1: OF Heston Kjerstad - Bal Round 2: 1B Triston Casas - Bos |
| 1st Team | 2nd Team |
| Pre-Season | |
| Fightins | Gurdon Panthers |
|
SP
Andrew Painter
Phi 2B Kristian Campbell Bos |
Round 5, 2nd Pick (C J.T. Realmuto Phi) |