| Week | Add | Drop |
| Week 1 |
Round 1: RP Alex Colome  | |
| Week 2 |
Round 1: OF Michael Saunders  Round 2: SP Drew Pomeranz  |
Round 1: RP Brad Boxberger |
| Week 3 |
Round 1: RP Adam Conley  Round 2: 2B Jed Lowrie  |
Round 1: RP JJ Hoover  Round 2: 2B Cory Spangenberg  |
| Week 4 |
Round 1: C Geovany Soto  Round 2: RP Adam Conley |
Round 1: RP Adam Conley Round 2: RP Alex Colome |
| Week 5 |
Round 1: SP Rich Hill  Round 2: C Dioner Navarro  |
Round 1: SP Anthony DeSclafani Round 2: SP Garrett Richards |
| Week 6 |
Round 1: SS Brad Miller Round 2: 3B Derek Dietrich |
Round 1: C Devin Mesoraco Round 2: SS Andrelton Simmons |
| Week 7 |
Round 1: RP Sam Dyson  Round 2: RP Arodys Vizcaino  |
Round 1: RP Shawn Tolleson Round 2: C Geovany Soto |
| Week 8 |
Round 1: OF Brandon Guyer Round 2: 2B Jed Lowrie |
Round 1: 2B Jed Lowrie Round 2: 3B Derek Dietrich |
| Week 9 |
Round 1: DH Kendrys Morales  |
Round 1: RP Sam Dyson |
| Week 10 |
Round 1: SP Jerad Eickhoff  Round 2: SP Matt Shoemaker |
Round 1: SP Yordano Ventura Round 2: SS Brad Miller |
| Week 11 |
Round 1: RP Shawn Kelley  Round 2: SP Daniel Mengden |
Round 1: OF Brandon Guyer Round 2: RP Adam Conley |
| Week 12 |
Round 1: SP Anthony DeSclafani |
Round 1: SP Kevin Gausman  |
| Week 13 |
Round 2: SP Danny Duffy |
Round 2: SP Daniel Mengden |
| Week 16 |
Round 1: SP Michael Pineda  Round 2: SS Andrelton Simmons |
Round 2: RP Shawn Kelley Round 2: RP Arodys Vizcaino |
| Week 17 |
Round 1: SP James Shields Round 2: OF Bradley Zimmer  |
Round 1: RP Hector Rondon  Round 2: RP Jon Papelbon |
| Week 18 |
Round 1: SP Mike Leake  |
Round 1: RP Steve Cishek  Round 2: SS Andrelton Simmons |
| Week 19 |
Round 1: 1B Pedro Alvarez Round 2: 2B Howie Kendrick |
Round 2: 2B Jed Lowrie |
| Week 21 |
Round 1: SP Drew Smyly |
Round 1: SP James Shields |
| 1st Team | 2nd Team | Votes |
| Week 4 | ||
| Santa’s Royal Giants | NYSE: USB | Decision |
|
C
Blake Swihart
2B Rougned Odor |
C
Devin Mesoraco
2B Jason Kipnis |
Approved 12-1. See Breakdown |
| Week 7 | ||
| Santa’s Royal Giants | NYSE: USB | Decision |
|
SP
Raisel Iglesias
|
C
Salvador Perez
|
Approved 13-0. See Breakdown |
| Week 9 | ||
| Santa’s Royal Giants | A CLEVER TEAM NAME | Decision |
C
Travis d'Arnaud
 |
RP
Jon Papelbon
|
Approved 9-1. See Breakdown |
| Week 14 | ||
| Santa’s Royal Giants | Don Mattingly | Decision |
|
SP
Jerad Eickhoff
|
RP
Hector Rondon
|
Approved 12-0. See Breakdown |