| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jared Jones - Pit Round 2: C Elias Diaz - Col |
Round 1: 3B Curtis Mead - TB |
| Week 1 |
Round 1: C Travis d'Arnaud - Atl Round 2: RP Ronel Blanco - Hou |
Round 2: C Tyler Stephenson - Cin |
| Week 3 |
Round 1: SP Javier Assad - ChN |
Round 1: SS Masyn Winn - StL Round 2: OF Nelson Velazquez - KC |
| Week 4 |
Round 1: OF Nelson Velazquez - KC Round 2: SP Christian Scott - NYN |
Round 1: SP Patrick Sandoval - LAA Round 2: SP Patrick Sandoval - LAA |
| Week 5 |
Round 1: OF Max Kepler - Min Round 2: RP Yennier Cano - Bal |
Round 2: SP Jonathan Gray - Tex Round 2: OF Nelson Velazquez - KC |
| Week 6 |
Round 1: SS Oswaldo Cabrera - NYA Round 2: 1B Joshua Bell - Ari |
Round 1: OF Jarred Kelenic - Atl Round 2: SP Triston McKenzie - Cle Round 2: SP Jose Quintana - NYN |
| Week 7 |
Round 1: 2B Josh Rojas - Sea Round 2: C Tyler Stephenson - Cin |
Round 1: 1B Joshua Bell - Ari |
| Week 8 |
Round 2: C Tyler Stephenson - Cin | |
| Week 9 |
Round 1: OF JJ Bleday - Oak Round 1: OF JJ Bleday - Oak Round 2: C Tyler Stephenson - Cin |
Round 1: 2B Josh Rojas - Sea Round 1: 2B Josh Rojas - Sea Round 2: OF Mitch Haniger - Sea Round 2: C Travis d'Arnaud - Atl |
| Week 10 |
Round 1: OF Masataka Yoshida - Bos Round 2: 3B Elehuris Montero - Col |
Round 1: RP Yennier Cano - Bal Round 2: 3B Brett Baty - NYN |
| Week 11 |
Round 1: C Henry Davis - Pit | |
| Week 12 |
Round 2: C Jacob Stallings - Col |
Round 2: C Tyler Stephenson - Cin Round 2: C Henry Davis - Pit |
| Week 13 |
Round 1: C Tyler Stephenson - Cin Round 2: 2B Luis Garcia - Was |
Round 1: C Jacob Stallings - Col |
| Week 14 |
Round 1: SS Jose Caballero - TB Round 2: SP Brayan Bello - Bos |
Round 2: SP Javier Assad - ChN |
| Week 15 |
Round 1: OF Connor Joe - Pit |
Round 1: 3B Elehuris Montero - Col |
| Week 16 |
Round 1: OF Jo Adell - LAA |
Round 1: OF Max Kepler - Min |
| Week 18 |
Round 1: 1B David Fry - Cle Round 2: 3B Ke'Bryan Hayes - Pit |
Round 1: SP Christian Scott - NYN Round 2: SS Oswaldo Cabrera - NYA |
| Week 19 |
Round 1: SS Jeremy Pena - Hou |
Round 1: SP MacKenzie Gore - Was |
| Week 20 |
Round 1: SP Eduardo Rodriguez - Ari |
Round 1: OF Connor Joe - Pit |
| 1st Team | 2nd Team |
| Pre-Season | |
| Warning Track Power | Gwinnett Stripers |
|
2B
Jose Altuve
Hou |
|
| Pre-Season | |
| Warning Track Power | Bumgaardians |
|
SP
Logan Gilbert
Sea |
|
| Week 4 | |
| Warning Track Power | Santa’s Royal Giants |
|
3B
Alex Bregman
Hou SP Dylan Cease SD SP Freddy Peralta Mil RP Evan Phillips LAD |
SP
Jose Quintana
NYN SP Jonathan Gray Tex 3B Rafael Devers Bos SP Patrick Sandoval LAA |