| Week | Add | Drop |
| Week 1 |
Round 1: SP John Means - Bal | |
| Week 2 |
Round 1: RP Diego Castillo - Sea Round 2: RP Emmanuel Clase - Cle |
Round 2: SP James Paxton - Sea |
| Week 3 |
Round 1: RP Yimi Garcia - Hou Round 2: SP Kevin Gausman - Tor |
Round 1: RP Jordan Romano - Tor Round 2: RP Rafael Montero - Sea |
| Week 4 |
Round 1: SP Jonathan Gray - Tex Round 2: C James McCann - NYN |
Round 1: SP AJ Puk - Oak Round 2: C Tom Murphy - Sea |
| Week 5 |
Round 1: RP Huascar Ynoa - Atl Round 2: 3B Dylan Moore - Sea |
Round 2: OF Victor Robles - Was |
| Week 6 |
Round 1: 2B Jurickson Profar - SD Round 2: 2B Jake Cronenworth - SD |
Round 1: RP Diego Castillo - Sea Round 2: 2B Jonathan India - Cin |
| Week 7 |
Round 1: OF Josh Naylor - Cle Round 2: OF Hunter Dozier - KC |
Round 2: C Joey Bart - SF |
| Week 8 |
Round 1: SP Germán Márquez - Col | |
| Week 9 |
Round 1: OF Pavin Smith - Ari | |
| Week 10 |
Round 1: 2B Zach McKinstry - LAD Round 2: SP Jordan Montgomery - NYA |
Round 1: RP Emmanuel Clase - Cle Round 2: SP Jonathan Gray - Col |
| Week 11 |
Round 1: RP Tucker Davidson - Atl | |
| Week 12 |
Round 1: SP Erick Fedde - Was | |
| Week 13 |
Round 1: SS Miguel Rojas - Mia Round 2: SP Kenta Maeda - Min |
Round 1: 2B Jurickson Profar - SD Round 2: SP Erick Fedde - Was |
| Week 14 |
Round 1: SP Jonathan Gray - Tex Round 2: OF Anthony Santander - Bal |
Round 2: SP Jordan Montgomery - NYA |
| Week 15 |
Round 2: 1B Eric Hosmer - SD |
Round 2: OF Pavin Smith - Ari |
| Week 17 |
Round 1: SP Touki Toussaint - Atl Round 2: 3B Jeff McNeil - NYN |
Round 1: SP Cristian Javier - Hou Round 2: SP Zach Eflin - Phi |
| Week 18 |
Round 1: RP Diego Castillo - Sea |
Round 1: SP Touki Toussaint - Atl |
| Week 20 |
Round 1: OF Tyler Naquin - Cin Round 2: OF Jake Fraley - Cin |
Round 1: SP Jose Urquidy - Hou Round 2: SP Chris Paddack - SD |
| Week 22 |
Round 1: SP Vladimir Gutierrez - Cin Round 2: RP Carlos Estevez - Col |
Round 2: SP Kenta Maeda - Min |
| 1st Team | 2nd Team |
| Week 9 | |
| Bronx Zoo | My Oh My |
|
OF
Mike Trout
LAA SS Luis Urias Mil 2B Jake Cronenworth SD |
SP
Charlie Morton
Atl 3B Anthony Rendon LAA SS Francisco Lindor NYN SP Zach Eflin Phi |
| Week 13 | |
| Bronx Zoo | Fresh Shaven Players Only |
|
SS
Javier Baez
Det 1B Yulieski Gurriel Hou |
2B
D.J. LeMahieu
NYA 1B Paul Goldschmidt StL |
| Week 14 | |
| Bronx Zoo | Yankee Pride |
|
OF
Joey Gallo
NYA SP Germán Márquez Col SP Trevor Rogers Mia |
SP
Max Scherzer
NYN SP Stephen Strasburg Was OF Raimel Tapia Tor SP Freddy Peralta Mil |