| Week | Add | Drop |
| Pre-Season |
Round 2: 2B Garrett Hampson - Col Round 2: C Wilson Ramos - Det | |
| Week 1 |
Round 1: 2B Luis Arraez - Min Round 2: OF Kyle Isbel - KC |
Round 1: RP Drew Pomeranz - SD Round 2: OF Hunter Renfroe - Bos |
| Week 2 |
Round 1: SP Cesar Valdez - Bal Round 2: SP Adrian Houser - Mil |
Round 1: RP Anthony Bass - Mia Round 2: RP Greg Holland - KC |
| Week 3 |
Round 1: OF Cedric Mullins II - Bal Round 2: OF Chris Owings - Col |
Round 1: OF Kyle Isbel - KC Round 2: SP Randy Dobnak - Min |
| Week 4 |
Round 1: SP Kohei Arihara - Tex Round 2: C Mike Zunino - TB |
Round 2: SP Zach Davies - ChN |
| Week 5 |
Round 1: RP Josh Staumont - KC Round 2: OF Raimel Tapia - Col |
Round 1: C Pedro Severino - Bal Round 2: 1B Edwin Rios - LAD |
| Week 6 |
Round 1: OF Austin Martin - Min Round 2: SP Alek Manoah - Tor | |
| Week 7 |
Round 1: SP Yusei Kikuchi - Tor Round 2: OF Josh Naylor - Cle |
Round 1: SP Merrill Kelly - Ari Round 2: 3B Dylan Moore - Sea |
| Week 8 |
Round 1: 2B Vidal Brujan - TB Round 2: SP Kris Bubic - KC | |
| Week 9 |
Round 1: OF Seth Brown - Oak Round 2: SS Edmundo Sosa - StL |
Round 2: RP Josh Staumont - KC |
| Week 10 |
Round 1: 2B Jonathan Schoop - Det | |
| Week 11 |
Round 1: SP Vladimir Gutierrez - Cin |
Round 1: SS Edmundo Sosa - StL |
| Week 12 |
Round 1: RP Lucas Sims - Cin Round 2: SS Amed Rosario - Cle | |
| Week 13 |
Round 1: RP Jordan Romano - Tor Round 2: 1B Nick Pratto - KC |
Round 1: SP Kris Bubic - KC Round 2: RP Lucas Sims - Cin |
| Week 14 |
Round 1: SP Shane Baz - TB Round 2: OF Avisail Garcia - Mia |
Round 1: 1B Nick Pratto - KC Round 2: OF Chris Owings - Col |
| Week 15 |
Round 1: OF Chas McCormick - Hou |
Round 1: SS J.P. Crawford - Sea |
| Week 17 |
Round 1: OF Estevan Florial - NYA Round 2: OF LaMonte Wade Jr - SF |
Round 2: OF Chas McCormick - Hou |
| Week 18 |
Round 1: 3B Abraham Toro - Sea |
Round 1: OF Estevan Florial - NYA |
| Week 19 |
Round 1: C Kyle Farmer - Cin Round 2: RP Chad Green - NYA |
Round 1: OF Andrew Benintendi - KC Round 2: OF LaMonte Wade Jr - Min |
| Week 20 |
Round 1: SP Luis Gil - NYA Round 2: OF Jake Meyers - Hou | |
| Week 22 |
Round 1: SP Triston McKenzie - Cle |
Round 1: SP Yusei Kikuchi - Sea |
| 1st Team | 2nd Team |
| Week 8 | |
| Temple of Doom 26 | Page Fence Giants |
|
2B
Starlin Castro
Was 1B Andrew Vaughn ChA SP Alek Manoah Tor |
SP
Michael Pineda
Min SP Lance McCullers Hou 1B Christian Walker Ari |
| Week 8 | |
| Temple of Doom 26 | Nashville Standard Giants |
|
SS
Jeter Downs
Bos |
OF
Michael Brantley
Hou |
| Week 13 | |
| Temple of Doom 26 | Page Fence Giants |
|
SP
Vladimir Gutierrez
Cin SP Josh Fleming TB |
SP
Nathan Eovaldi
Bos OF Kike Hernandez Bos |
| Week 13 | |
| Temple of Doom 26 | Tuesday Afternoon |
|
SP
Tyler Glasnow
TB SP Dylan Cease ChA 2B Vidal Brujan TB OF Austin Martin Min |
1B
Joey Votto
Cin SP Lucas Giolito ChA SP Robbie Ray Sea SP Ian Anderson Atl |