| Week | Add | Drop |
| Pre-Season |
Round 1: SP Jack Flaherty - Det Round 2: OF Dominic Canzone - Sea Round A: SP Shota Imanaga - ChN Round B: C Ethan Salas - SD |
Round A: C Alejandro Kirk - Tor Round B: SP Brady Singer - KC |
| Week 1 |
Round 2: 3B Trey Lipscomb - Was | |
| Week 2 |
Round 1: SP Reese Olson - Det Round 2: C Carson Kelly - Det | |
| Week 3 |
Round 1: 2B Brice Turang - Mil Round 2: SP Dane Dunning - Tex |
Round 2: C Carson Kelly - Det |
| Week 4 |
Round 1: OF Esteury Ruiz - Oak |
Round 1: OF Dominic Canzone - Sea |
| Week 5 |
Round 1: OF Wilyer Abreu - Bos |
Round 2: SP Griffin Canning - LAA |
| Week 6 |
Round 1: 3B Tyler Black - Mil Round 2: SP Garrett Crochet - ChA |
Round 1: 3B Mark Vientos - NYN Round 2: 3B Trey Lipscomb - Was |
| Week 7 |
Round 1: RP José Alvarado - Phi |
| 1st Team | 2nd Team |
| Pre-Season | |
| New Orleans Zephyrs | Future Dynasty |
|
Round 3, 5th Pick (2B Jorge Polanco Sea) |
3B
Noelvi Marte
Cin |
| Pre-Season | |
| New Orleans Zephyrs | Bad Reputation |
|
Round 5, 5th Pick (SS C.J. Abrams Was) Round 8, 5th Pick (2B Brandon Drury LAA) |
RP
Emmanuel Clase
Cle OF Dylan Crews Was |
| Week 5 | |
| New Orleans Zephyrs | Whiz Kids |
|
RP
Josh Hader
Hou OF Bryan Reynolds Pit |
C
Francisco Álvarez
NYN SS Jackson Holliday Bal OF Chase DeLauter Cle |
| Week 6 | |
| New Orleans Zephyrs | Bad Reputation |
|
SP
Freddy Peralta
Mil RP Emmanuel Clase Cle |
3B
Orelvis Martinez
Tor OF Spencer Jones NYA |
| Week 6 | |
| New Orleans Zephyrs | Irish Panthers |
|
SP
Kevin Gausman
Tor SP Reese Olson Det 2B Edouard Julien Min |
OF
Jordan Walker
StL |
| Week 7 | |
| New Orleans Zephyrs | Natural Grass |
|
3B
Eugenio Suarez
Ari C Francisco Álvarez NYN |
RP
Daniel Hudson
LAD SP Michael King SD |