| Week | Add | Drop |
| Pre-Season |
Round 1: OF Joey Gallo - Was Round 2: 2B Whit Merrifield - Phi Round A: SS Luisangel Acuna - NYN |
Round A: C Gary Sanchez - Mil |
| Week 1 |
Round 1: SP Zack Littell - TB Round 2: 2B Cavan Biggio - Tor | |
| Week 2 |
Round 1: OF MJ Melendez - KC Round 2: RP James McArthur - KC | |
| Week 3 |
Round 1: OF Joey Loperfido - Hou Round 2: 2B Luis Garcia - Was |
Round 2: 1B Bobby Dalbec - Bos |
| Week 4 |
Round 1: 3B Josh Smith - Tex Round 2: C Travis d'Arnaud - Atl |
Round 2: RP Jose Leclerc - Tex |
| Week 5 |
Round 1: OF Daulton Varsho - Tor Round 2: 2B Brandon Lowe - TB |
Round 1: OF Matt Wallner - Min Round 2: OF Joey Gallo - Was |
| Week 6 |
Round 1: SP Hayden Wesneski - ChN Round 2: OF Brent Rooker - Oak |
Round 1: SP Chase Silseth - LAA Round 2: RP José Alvarado - Phi |
| 1st Team | 2nd Team |
| Pre-Season | |
| Irish Panthers | Future Dynasty |
|
Round 1, 11th Pick (OF Chas McCormick Hou) |
SP
Tyler Glasnow
LAD |
| Pre-Season | |
| Irish Panthers | Whiz Kids |
|
Round 5, 11th Pick (SP Bryce Miller Sea) |
RP
Kyle Finnegan
Was |
| Pre-Season | |
| Irish Panthers | Don Mattingly |
|
Round 8, 11th Pick (SS Ha-seong Kim SD) |
RP
Kendall Graveman
Hou |
| Week 6 | |
| Irish Panthers | New Orleans Zephyrs |
|
OF
Jordan Walker
StL |
SP
Kevin Gausman
Tor SP Reese Olson Det 2B Edouard Julien Min |