| Week | Add | Drop |
| Pre-Season |
Round 2: SP José Soriano - LAA | |
| Week 3 |
Round 2: SP Andre Pallante - StL Round 3: OF Sal Frelick - Mil |
| 1st Team | 2nd Team |
| Pre-Season | |
| Salem Red Sox | Deputy Dawg |
|
SS
Carlos Correa
Min |
SP
Roki Sasaki
LAD |
| Pre-Season | |
| Salem Red Sox | Mayo on That? |
|
OF
Mike Trout
LAA |
OF
Dylan Crews
Was Round 1, 4th Pick (SS Sebastian Walcott Tex) |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
OF
Juan Soto
NYN Round 8, 10th Pick (SS Jordan Lawlar Ari) |
3B
Alex Bregman
Bos SS Bo Bichette Tor RP Emmanuel Clase Cle OF Jarren Duran Bos |
| Pre-Season | |
| Salem Red Sox | Deputy Dawg |
|
2B
Matt McLain
Cin |
OF
Jackson Merrill
SD |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
OF
Jackson Merrill
SD Round 1, 10th Pick (SP Grayson Rodriguez Bal) Round 1, 4th Pick (SS Sebastian Walcott Tex) |
SP
Zack Wheeler
Phi OF Oneil Cruz Pit |
| Pre-Season | |
| Salem Red Sox | Inland Empire 66ers |
|
3B
Connor Norby
Mia |
OF
Teoscar Hernández
LAD |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
SP
Ryan Pepiot
TB |
1B
Bryce Eldridge
SF |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
Round 3, 10th Pick (OF Walker Jenkins Min) |
3B
Connor Norby
Mia |
| Pre-Season | |
| Salem Red Sox | Deputy Dawg |
|
OF
Brenton Doyle
Col |
1B
Christian Encarnacion-Strand
Cin |
| Pre-Season | |
| Salem Red Sox | Mayo on That? |
|
SP
Aaron Nola
Phi |
Round 3, 4th Pick (SP Pablo Lopez Min) |
| Pre-Season | |
| Salem Red Sox | Inland Empire 66ers |
|
SP
George Kirby
Sea |
Round 3, 9th Pick (1B Jac Caglianone KC) |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
Round 3, 4th Pick (SP Pablo Lopez Min) |
OF
Roman Anthony
Bos |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
Round 7, 10th Pick (RP Trevor Megill Mil) |
Round 12, 7th Pick (OF Matt Wallner Min) Round 13, 7th Pick (SP Ryan Pepiot TB) Round 14, 7th Pick (RP Pete Fairbanks TB) Round 15, 7th Pick (RP Justin Martinez Ari) Round 14, 1st Pick (SP Dustin May LAD) |
| Pre-Season | |
| Salem Red Sox | Deputy Dawg |
|
3B
Jordan Westburg
Bal Round 2, 10th Pick (C Salvador Perez KC) |
OF
Cody Bellinger
NYA 2B Matt McLain Cin Round 8, 1st Pick (1B Bryce Eldridge SF) |
| Pre-Season | |
| Salem Red Sox | Bowling Green Hot Rods |
|
Round 3, 9th Pick (1B Jac Caglianone KC) Round 8, 1st Pick (1B Bryce Eldridge SF) |
RP
Felix Bautista
Bal Round 9, 7th Pick (RP Kyle Finnegan Was) Round 10, 7th Pick (SP MacKenzie Gore Was) Round 11, 7th Pick (2B Luisangel Acuna NYN) |
| Week 3 | |
| Salem Red Sox | Bowling Green Hot Rods |
|
OF
George Springer
Tor SP MacKenzie Gore Was RP Kyle Finnegan Was |
SS
Jordan Lawlar
Ari OF Walker Jenkins Min 2B Christian Moore LAA |
| Week 3 | |
| Salem Red Sox | Deputy Dawg |
|
SP
José Soriano
LAA OF JJ Bleday Oak |
SP
Carlos Rodon
NYA OF Evan Carter Tex |
| Week 6 | |
| Salem Red Sox | Bowling Green Hot Rods |
|
SP
Zack Wheeler
Phi SP Carlos Rodon NYA |
SP
Grayson Rodriguez
Bal 2B Travis Bazzana Cle SP Roki Sasaki LAD |