| Week | Add | Drop |
| Pre-Season |
Round 1: OF Alan Roden - Tor Round 3: C Miguel Amaya - ChN Round A: SP Shane Bieber - Cle |
Round 1: OF Zac Veen - Col Round A: 1B Dom Smith - NYA |
| Week 1 |
Round 2: RP Camilo Doval - SF Round 3: OF Max Kepler - Phi |
Round 2: OF Alan Roden - Tor Round 3: 1B Jose Miranda - Min |
| Week 2 |
Round 2: SP Matt Boyd - ChN Round 3: C Carlos Narvaez - Bos |
Round 2: RP Camilo Doval - SF Round 3: OF Jurickson Profar - Atl |
| Week 3 |
Round 1: 1B Matt Mervis - Mia Round 2: SP Shane Smith - ChA Round 3: OF Alex Call - Was |
Round 2: C Carlos Narvaez - Bos Round 3: OF Max Kepler - Phi |
| Week 4 |
Round 2: SP Hunter Dobbins - Bos |
Round 2: OF Alex Call - Was |
| Week 5 |
Round 2: OF Jordan Beck - Col Round 3: C Francisco Álvarez - NYN |
Round 2: 1B Colt Keith - Det Round 3: C Alejandro Kirk - Tor |
| 1st Team | 2nd Team |
| Pre-Season | |
| NYSE: PG | Iowa Cubs |
|
OF
Adolis Garcia
Tex |
Round 10, 6th Pick (SP Nestor Cortes Jr. Mil) |
| Pre-Season | |
| NYSE: PG | Bowling Green Hot Rods |
|
SP
Shota Imanaga
ChN |
Round 4, 7th Pick (OF Jurickson Profar Atl) |