| Week | Add | Drop |
| Pre-Season |
Round 2: SP Griffin Canning - LAA Round A: SP Shota Imanaga - ChN |
Round A: C Travis d'Arnaud - Atl |
| Week 1 |
Round 2: RP Hunter Harvey - Was | |
| Week 2 |
Round 1: C Joey Bart - Pit Round 2: SP Colin Rea - Mil | |
| Week 3 |
Round 1: SP Trevor Williams - Was |
Round 1: SP Griffin Canning - LAA |
| Week 4 |
Round 2: SS Gabriel Arias - Cle |
Round 2: 1B Carlos Santana - Min |
| Week 5 |
Round 1: SS Paul DeJong - ChA Round 2: RP Reed Garrett - NYN |
Round 2: RP Hunter Harvey - Was Round 2: SP Trevor Williams - Was |
| Week 6 |
Round 1: SP Trevor Williams - Was Round 2: OF Wenceel Perez - Det |
Round 1: OF Austin Hays - Bal Round 2: SS Paul DeJong - ChA |
| 1st Team | 2nd Team |
| Pre-Season | |
| Inland Empire 66ers | Deputy Dawg |
|
Round 10, 6th Pick (SP Frankie Montas Cin) |
2B
Brandon Lowe
TB |
| Pre-Season | |
| Inland Empire 66ers | Peoria Javelinas |
|
Round 3, 6th Pick (OF James Outman LAD) |
SP
Kevin Gausman
Tor |
| Pre-Season | |
| Inland Empire 66ers | Bowling Green Hot Rods |
|
3B
Austin Riley
Atl 1B Peter Alonso NYN OF James Wood Was Round 13, 6th Pick (RP Tanner Scott Mia) |
1B
Freddie Freeman
LAD RP Emmanuel Clase Cle 2B Matt McLain Cin Round 17, 4th Pick (OF Jarren Duran Bos) Round 18, 4th Pick (OF Austin Hays Bal) Round 19, 4th Pick (C Gary Sanchez Mil) |
| Pre-Season | |
| Inland Empire 66ers | Bowling Green Hot Rods |
|
C
Gary Sanchez
Mil SP Kevin Gausman Tor |
OF
Chase DeLauter
Cle OF Walker Jenkins Min |
| Week 4 | |
| Inland Empire 66ers | Bowling Green Hot Rods |
|
OF
Jarren Duran
Bos |
RP
Andres Munoz
Sea |
| Week 5 | |
| Inland Empire 66ers | Peoria Javelinas |
|
1B
Freddie Freeman
LAD SP Max Fried Atl 2B Matt McLain Cin |
SP
Zach Wheeler
Phi OF Christian Yelich Mil 2B Marcus Semien Tex |
| Week 5 | |
| Inland Empire 66ers | Up Your Butt Jobu |
|
1B
Ryan Mountcastle
Bal SP Shane McClanahan TB RP Andres Munoz Sea |
RP
Kenley Jansen
Bos SP Blake Snell SF 3B Alec Bohm Phi |