| Week | Add | Drop |
| Pre-Season |
Round 1: SP Reid Detmers - LAA Round 2: 2B Brendan Donovan - StL Round A: OF Jung Hoo Lee - SF | |
| Week 2 |
Round 1: OF Mitch Haniger - Sea Round 2: 1B Jared Walsh - ChA |
Round 1: SP MacKenzie Gore - Was Round 2: RP Tanner Scott - SD |
| Week 3 |
Round 1: 2B Vaughn Grissom - Bos |
Round 1: SP Brandon Woodruff - Mil |
| Week 4 |
Round 1: 3B Nick Senzel - ChA Round 2: OF Daulton Varsho - Tor |
Round 1: 1B Jose Abreu - Hou Round 2: 3B Yoan Moncada - ChA |
| Week 5 |
Round 1: SP Clayton Kershaw - LAD Round 2: SP Miles Mikolas - StL |
Round 1: SP Hunter Brown - Hou Round 2: 1B Jared Walsh - ChA |
| Week 6 |
Round 1: OF Jo Adell - LAA Round 2: SP Dean Kremer - Bal |
Round 1: SP Clayton Kershaw - LAD Round 2: SP Miles Mikolas - StL |
| Week 7 |
Round 1: SP Chris Paddack - Min |
Round 1: OF Jo Adell - LAA Round 2: 2B Vaughn Grissom - Bos |
| Week 8 |
Round 2: C Gary Sanchez - Mil |
Round 2: SP Reid Detmers - LAA |
| Week 9 |
Round 1: SP Austin Gomber - Col Round 1: SP Austin Gomber - Col Round 2: 3B D.J. LeMahieu - NYA |
Round 2: 3B Nick Senzel - ChA |
| Week 10 |
Round 1: OF Andrew McCutchen - Pit Round 2: SP Cal Quantrill - Col |
Round 1: OF Mitch Haniger - Sea Round 2: SP Chris Paddack - Min |
| Week 11 |
Round 1: OF Masataka Yoshida - Bos Round 2: OF Alec Burleson - StL |
Round 1: 3B D.J. LeMahieu - NYA |
| Week 13 |
Round 2: SP Kyle Harrison - SF |
Round 2: OF Masataka Yoshida - Bos |
| Week 14 |
Round 1: 1B Ty France - Cin Round 2: OF Connor Joe - Pit |
Round 2: C Gary Sanchez - Mil |
| Week 15 |
Round 1: OF Jose Siri - TB |
Round 2: OF Jose Siri - TB Round 2: 1B Ty France - Cin |
| Week 16 |
Round 1: SP Merrill Kelly - Ari Round 2: SP Charlie Morton - Atl |
Round 1: DH Justin Turner - Sea |
| Week 17 |
Round 2: OF Connor Joe - Pit | |
| Week 18 |
Round 1: SS JJ Wetherholt - StL Round 2: SP Tyler Phillips - Phi |
Round 2: SP Jesus Luzardo - Mia |
| Week 19 |
Round 1: DH Justin Turner - Sea Round 2: OF Daulton Varsho - Tor |
Round 1: OF Daulton Varsho - Tor Round 2: SP Kyle Harrison - SF |
| Week 20 |
Round 1: 3B Isiah Kiner-Falefa - Pit |
Round 1: OF Daulton Varsho - Tor |
| Week 22 |
Round 1: OF Daulton Varsho - Tor |
Round 1: OF Andrew McCutchen - Pit |
| 1st Team | 2nd Team |
| Pre-Season | |
| 4 GAMERS | 12 ANGREY MEN |
|
OF
Billy McKinney
Pit |
|
| Pre-Season | |
| 4 GAMERS | Cal Ripken |
|
SP
Justin Verlander
Hou 3B Nolan Arenado StL |
|
| Pre-Season | |
| 4 GAMERS | Cal Ripken |
|
OF
Jasson Dominguez
NYA 1B Kyle Manzardo Cle |
|
| Pre-Season | |
| 4 GAMERS | Cal Ripken |
| Pre-Season | |
| 4 GAMERS | Michigan Maulers 4 |
|
C
Willson Contreras
StL |
C
William Contreras
Mil |
| Pre-Season | |
| 4 GAMERS | Built 4 Speed |
|
C
Keibert Ruiz
Was |
3B
Yoan Moncada
ChA |
| Week 4 | |
| 4 GAMERS | Built 4 Speed |
|
3B
Rafael Devers
Bos |
1B
Bryce Harper
Phi |
| Week 11 | |
| 4 GAMERS | Leviticus |
|
OF
Nick Castellanos
Phi |
OF
Jordan Walker
StL |
| Week 11 | |
| 4 GAMERS | Cal Ripken |
|
SP
Shane McClanahan
TB |
SP
Luis Severino
NYN |
| Week 11 | |
| 4 GAMERS | 12 ANGREY MEN |
|
SP
Sandy Alcantara
Mia |
SP
Justin Steele
ChN |
| Week 12 | |
| 4 GAMERS | Michigan Maulers 4 |
|
Round 6, 10th Pick (SP Gavin Williams Cle) |
RP
Jhoan Duran
Min |
| Week 16 | |
| 4 GAMERS | Cal Ripken |
|
Round 4, 10th Pick (OF Jorge Soler LAA) |
3B
Nolan Arenado
StL |
| Week 17 | |
| 4 GAMERS | Built 4 Speed |
|
SP
Justin Steele
ChN RP Camilo Doval SF |
SS
Willy Adames
Mil SP Dylan Cease SD |