| Week | Add | Drop |
| Pre-Season |
Round 1: 3B J.D. Davis - NYA Round 2: 2B Brice Turang - Mil Round A: SS Jackson Merrill - SD |
Round A: C Jake Rogers - Det |
| Week 1 |
Round 1: SP Jordan Hicks - SF Round 2: SP Dane Dunning - Tex | |
| Week 2 |
Round 1: SP Sean Manaea - NYN Round 2: C Joey Bart - Pit | |
| Week 3 |
Round 1: SP Bailey Ober - Min Round 2: OF Jurickson Profar - SD |
Round 2: 3B J.D. Davis - NYA |
| Week 4 |
Round 1: SP Jameson Taillon - ChN Round 2: OF Daulton Varsho - Tor |
Round 1: SP Kenta Maeda - Det Round 2: C Joey Bart - Pit |
| Week 5 |
Round 1: RP Hector Neris - ChN Round 2: C Patrick Bailey - SF |
Round 1: RP Adbert Alzolay - ChN Round 2: SP Sean Manaea - NYN Round 2: C Alejandro Kirk - Tor |
| Week 6 |
Round 1: 2B Luis Rengifo - LAA Round 2: OF Dylan Carlson - TB | |
| Week 7 |
Round 1: 2B Nick Gonzales - Pit Round 2: C Tyler Soderstrom - Oak |
Round 1: 3B Curtis Mead - TB Round 2: SP Dane Dunning - Tex |
| Week 8 |
Round 1: OF Heliot Ramos - SF Round 2: SS Marco Luciano - SF |
Round 1: OF Dylan Carlson - TB Round 2: SS Tim Anderson - Mia |
| Week 9 |
Round 1: 3B Dylan Moore - Sea Round 1: 3B Dylan Moore - Sea Round 2: RP Tanner Scott - SD |
Round 2: OF Cedric Mullins II - Bal Round 2: C Tyler Soderstrom - Oak Round 2: C Patrick Bailey - SF Round 2: OF Sal Frelick - Mil |
| Week 10 |
Round 1: C Patrick Bailey - SF Round 2: SP Ben Lively - Cle | |
| Week 12 |
Round 1: RP Tanner Scott - SD Round 2: C Tyler Soderstrom - Oak |
Round 2: 3B Dylan Moore - Sea |
| Week 13 |
Round 1: RP Tanner Scott - SD |
Round 1: SS Marco Luciano - SF |
| Week 14 |
Round 1: OF Luis Matos - SF |
Round 1: RP Hector Neris - Hou |
| Week 15 |
Round 1: 2B Luis Garcia - Was |
Round 1: C Tyler Soderstrom - Oak Round 2: OF Luis Matos - SF |
| Week 16 |
Round 1: OF Juan Yepez - Was |
Round 1: OF Daulton Varsho - Tor |
| Week 18 |
Round 1: 1B Jac Caglianone - KC Round 2: SS Dansby Swanson - ChN |
Round 2: RP Jordan Romano - Tor |
| Week 19 |
Round 1: SP Paul Blackburn - NYN Round 2: OF Joc Pederson - Ari |
Round 1: RP Evan Phillips - LAD Round 2: SP Jordan Hicks - SF |
| Week 20 |
Round 1: SP Tyler Mahle - Tex Round 2: C Austin Wells - NYA |
Round 1: 2B Nick Gonzales - Pit Round 2: C Elias Diaz - SD |
| Week 22 |
Round 2: C Adrian Del Castillo - Ari |
Round 2: SP Tyler Mahle - Tex |
| 1st Team | 2nd Team |
| Pre-Season | |
| Palm Beach Cardinals | Mama's Boys |
|
C
Willson Contreras
StL |
|
| Pre-Season | |
| Palm Beach Cardinals | Cedar Rapids Kernels |
|
1B
Paul Goldschmidt
StL |
1B
Freddie Freeman
LAD |
| Pre-Season | |
| Palm Beach Cardinals | Gizzy |
|
OF
Kyle Tucker
Hou |
SS
Jordan Lawlar
Ari 1B Vinnie Pasquantino KC |
| Pre-Season | |
| Palm Beach Cardinals | Dave's Destroyers III |
|
OF
Spencer Steer
Cin |
|
| Pre-Season | |
| Palm Beach Cardinals | Gizzy |
|
OF
Spencer Steer
Cin |
|
| Pre-Season | |
| Palm Beach Cardinals | Maine Black Bears |
|
2B
Xander Bogaerts
SD |
|
| Week 4 | |
| Palm Beach Cardinals | Erie SeaWolves |
|
1B
Freddie Freeman
LAD SP Casey Mize Det SP Bailey Ober Min |
SP
Dylan Cease
SD SP Logan Webb SF OF Riley Greene Det |
| Week 12 | |
| Palm Beach Cardinals | Maine Black Bears |
|
OF
Evan Carter
Tex |
OF
Randy Arozarena
TB |
| Week 13 | |
| Palm Beach Cardinals | Basket Case |
|
2B
Mookie Betts
LAD |
SP
Justin Verlander
Hou SS Francisco Lindor NYN 3B Alex Bregman Hou |