| Week | Add | Drop |
| Pre-Season |
Round 1: C Miguel Amaya - ChN Round 2: 3B Zach Dezenzo - Hou | |
| Week 1 |
Round 1: RP Luke Jackson - Tex Round 2: SP Justin Slaten - Bos Round 3: 3B Josh Smith - Tex |
Round 3: 3B Zach Dezenzo - Hou |
| Week 2 |
Round 1: SP Griffin Canning - NYN Round 2: SS Kyle Farmer - Col Round 3: OF Garrett Mitchell - Mil |
Round 1: SP Justin Slaten - Bos Round 2: SP Justin Verlander - SF Round 3: OF Jo Adell - LAA |
| Week 3 |
Round 1: SP Kumar Rocker - Tex Round 3: SS Adael Amador - Col |
Round 1: C Miguel Amaya - ChN Round 3: SP Kumar Rocker - Tex |
| Week 4 |
Round 1: SP Jose Quintana - Mil Round 2: RP Tommy Kahnle - Det Round 3: C Agustin Ramirez - Mia |
Round 1: 3B Josh Smith - Tex Round 2: SP Gavin Williams - Cle Round 3: C Danny Jansen - TB |
| Week 5 |
Round 1: SS J.P. Crawford - Sea Round 2: OF Matt Wallner - Min |
Round 1: RP Tommy Kahnle - Det Round 2: OF Garrett Mitchell - Mil |
| Week 6 |
Round 1: RP David Bednar - Pit Round 2: SP Justin Verlander - SF |
Round 1: OF Matt Wallner - Min Round 2: SS Kyle Farmer - Col |
| 1st Team | 2nd Team |
| Pre-Season | |
| Buffalo Yankees | Gizzy |
|
Round 6, 12th Pick (1B Colt Keith Det) |
3B
Connor Norby
Mia Round 19, 4th Pick (3B Ke'Bryan Hayes Pit) |
| Pre-Season | |
| Buffalo Yankees | Erie SeaWolves |
|
RP
Raisel Iglesias
Atl |
Round 6, 3rd Pick (OF Nick Castellanos Phi) |
| Pre-Season | |
| Buffalo Yankees | Erie SeaWolves |
|
SS
Carlos Correa
Min Round 18, 12th Pick (C Carson Kelly ChN) |
Round 7, 3rd Pick (SP Gavin Williams Cle) |
| Pre-Season | |
| Buffalo Yankees | Erie SeaWolves |
|
SP
Spencer Schwellenbach
Atl Round 19, 12th Pick (C Jonah Heim Tex) |
Round 6, 10th Pick (2B Travis Bazzana Cle) |